MAP4K3

Mitogen-activated protein kinase kinase kinase kinase 3 is a protein that in humans is encoded by the MAP4K3 gene. [5]

MAP4K3
Identifiers
Aliases	MAP4K3, GLK, MAPKKKK3, MEKKK 3, MEKKK3, RAB8IPL1, mitogen-activated protein kinase kinase kinase kinase 3
External IDs	OMIM: 604921 MGI: 2154405 HomoloGene: 2683 GeneCards: MAP4K3
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p22.1 Start 39,249,266 bp[1] End 39,437,301 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E3 Start 80,580,512 bp[2] End 80,728,485 bp[2]
Gene ontology Molecular function • transferase activity • protein kinase activity • protein serine/threonine kinase activity • nucleotide binding • GO:0001948 protein binding • ATP binding • kinase activity • MAP kinase kinase kinase kinase activity Cellular component • cytoplasm Biological process • response to tumor necrosis factor • protein phosphorylation • JNK cascade • GO:0007243 intracellular signal transduction • response to UV • phosphorylation • activation of MAPKKK activity • regulation of mitotic cell cycle • regulation of apoptotic process • signal transduction by protein phosphorylation • stress-activated protein kinase signaling cascade • activation of protein kinase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8491	225028
Ensembl	ENSG00000011566	ENSMUSG00000024242
UniProt	Q8IVH8	Q99JP0
RefSeq (mRNA)	NM_001270425 NM_003618	NM_001081357 NM_001290345 NM_001360278
RefSeq (protein)	NP_001257354 NP_003609	NP_001277274 NP_001347207
Location (UCSC)	Chr 2: 39.25 – 39.44 Mb	Chr 17: 80.58 – 80.73 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

References

1. GRCh38: Ensembl release 89: ENSG00000011566 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024242 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Mitogen-activated protein kinase kinase kinase kinase 3". Retrieved 2017-09-22.

Further reading

• Lam D, Dickens D, Reid EB, Loh SH, Moisoi N, Martins LM (2009). "MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins". Proc. Natl. Acad. Sci. U.S.A. 106 (29): 11978–83. doi:10.1073/pnas.0900608106. PMC 2707271. PMID 19587239.
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Ichikawa S, Koller DL, Padgett LR, Lai D, Hui SL, Peacock M, Foroud T, Econs MJ (2010). "Replication of previous genome-wide association studies of bone mineral density in premenopausal American women". J. Bone Miner. Res. 25 (8): 1821–9. doi:10.1002/jbmr.62. PMC 3153352. PMID 20200978.
• Yan L, Mieulet V, Burgess D, Findlay GM, Sully K, Procter J, Goris J, Janssens V, Morrice NA, Lamb RF (2010). "PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR". Mol. Cell. 37 (5): 633–42. doi:10.1016/j.molcel.2010.01.031. PMID 20227368.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
• Chuang HC, Lan JL, Chen DY, Yang CY, Chen YM, Li JP, Huang CY, Liu PE, Wang X, Tan TH (2011). "The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells". Nat. Immunol. 12 (11): 1113–8. doi:10.1038/ni.2121. PMID 21983831.
• Chen DY, Chuang HC, Lan JL, Chen YM, Hung WT, Lai KL, Tan TH (2012). "Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker". BMC Med. 10: 84. doi:10.1186/1741-7015-10-84. PMC 3424974. PMID 22867055.
• Schriever SC, Deutsch MJ, Adamski J, Roscher AA, Ensenauer R (2013). "Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism". J. Nutr. Biochem. 24 (5): 824–31. doi:10.1016/j.jnutbio.2012.04.018. PMID 22898570.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.