MAP1S

Microtubule-associated protein 1S is a protein that in humans is encoded by the MAP1S gene.[5][6][7][8][9]

MAP1S
Identifiers
Aliases	MAP1S, BPY2IP1, C19orf5, MAP8, VCY2IP-1, VCY2IP1, microtubule associated protein 1S
External IDs	OMIM: 607573 MGI: 2443304 HomoloGene: 10047 GeneCards: MAP1S
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 17,719,242 bp[1] End 17,734,513 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B3.3 Start 70,905,932 bp[2] End 70,917,529 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • deoxyribonuclease activity • microtubule binding • tubulin binding • actin filament binding • GO:0001948 protein binding • beta-tubulin binding • identical protein binding • actin binding Cellular component • cytosol • cell projection • microtubule cytoskeleton • spindle • synapse • cell junction • neuronal cell body • dendrite • nucleolus • perinuclear region of cytoplasm • microtubule • cytoskeleton • cell nucleus • cytoplasm • microtubule associated complex Biological process • neuron projection morphogenesis • regulation of chromatin disassembly • nervous system development • autophagy • brain development • microtubule bundle formation • mitochondrion transport along microtubule • microtubule cytoskeleton organization • apoptotic process • DNA metabolic process • axonogenesis • dendrite development • regulation of microtubule depolymerization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55201	270058
Ensembl	ENSG00000130479	ENSMUSG00000019261
UniProt	Q66K74	Q8C052
RefSeq (mRNA)	NM_001308363 NM_018174	NM_173013
RefSeq (protein)	NP_001295292 NP_060644	NP_766601
Location (UCSC)	Chr 19: 17.72 – 17.73 Mb	Chr 8: 70.91 – 70.92 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

MAP1S has been shown to interact with RASSF1.[10][11]

References

1. GRCh38: Ensembl release 89: ENSG00000130479 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019261 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Liu L, McKeehan WL (Feb 2002). "Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity". Genomics. 79 (1): 124–36. doi:10.1006/geno.2001.6679. PMC 3241999. PMID 11827465.
6. Orbán-Németh Z, Simader H, Badurek S, Tranciková A, Propst F (Jan 2005). "Microtubule-associated protein 1S, a short and ubiquitously expressed member of the microtubule-associated protein 1 family". J. Biol. Chem. 280 (3): 2257–65. doi:10.1074/jbc.M408984200. PMID 15528209.
7. Ding J, Valle A, Allen E, Wang W, Nardine T, Zhang Y, Peng L, Yang Y (January 2006). "Microtubule-associated protein 8 contains two microtubule binding sites". Biochem. Biophys. Res. Commun. 339 (1): 172–9. doi:10.1016/j.bbrc.2005.10.199. PMID 16297881.
8. Wong EY, Tse JY, Yao KM, Lui VC, Tam PC, Yeung WS (Feb 2004). "Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein". Biol. Reprod. 70 (3): 775–84. doi:10.1095/biolreprod.103.018531. PMID 14627543.
9. "Entrez Gene: MAP1S microtubule-associated protein 1S".
10. Liu L, Vo A, McKeehan WL (Mar 2005). "Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5". Cancer Res. 65 (5): 1830–8. doi:10.1158/0008-5472.CAN-04-3896. PMID 15753381.
11. Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F (Jun 2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Res. 64 (12): 4112–6. doi:10.1158/0008-5472.CAN-04-0267. PMID 15205320.

Further reading

• Liu L, Amy V, Liu G, McKeehan WL (2003). "Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells". In Vitro Cell. Dev. Biol. Anim. 38 (10): 582–94. doi:10.1290/1543-706X(2002)38<582:NCIMAT>2.0.CO;2. PMC 3225227. PMID 12762840.
• Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F (2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Res. 64 (12): 4112–6. doi:10.1158/0008-5472.CAN-04-0267. PMID 15205320.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Liu L, Vo A, McKeehan WL (2005). "Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5". Cancer Res. 65 (5): 1830–8. doi:10.1158/0008-5472.CAN-04-3896. PMID 15753381.
• Liu L, Vo A, Liu G, McKeehan WL (2005). "Putative tumor suppressor RASSF1 interactive protein and cell death inducer C19ORF5 is a DNA binding protein". Biochem. Biophys. Res. Commun. 332 (3): 670–6. doi:10.1016/j.bbrc.2005.05.006. PMC 3225229. PMID 15907802.
• Foster LJ, Rudich A, Talior I, Patel N, Huang X, Furtado LM, Bilan PJ, Mann M, Klip A (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.