Lutetium (177Lu) chloride

Lutetium (177Lu) chloride
Clinical data
Trade names	Lumark, EndolucinBeta
AHFS/Drugs.com	UK Drug Information
ATC code	none;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name (177Lu)lutetium(3+) trichloride;
CAS Number	16434-14-3;
PubChem CID	71587001;
DrugBank	DBSALT002634;
ChemSpider	32700269;
UNII	1U477369SN;
KEGG	D10828;
CompTox Dashboard (EPA)	DTXSID20167745 ;
Chemical and physical data
Formula	Cl3Lu
Molar mass	281.32 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [Cl-].[Cl-].[Cl-].[177Lu+3];
	InChI InChI=1S/3ClH.Lu/h3*1H;/q;;;+3/p-3/i;;;1+2; Key:AEDROEGYZIARPU-SUNKFXMWSA-K;

Lutetium (177Lu) chloride, sold under the brand name Lumark among others, is a radioactive compound used for radiolabeling other medicines.[1][2]

The most common side effects are anaemia (low red blood cell counts), thrombocytopenia (low blood platelet counts), leucopenia (low white blood cell counts), lymphopenia (low levels of lymphocytes, a particular type of white blood cell), nausea (feeling sick), vomiting and mild and temporary hair loss.[1]

Medical uses

Lutetium (177Lu) chloride is a radiopharmaceutical precursor, and it is not intended for direct use in patients.[1] It is to be used only for the radiolabeling of carrier molecules that have been specifically developed and authorised for radiolabeling with Lutetium (177Lu) chloride.[1]

Contraindications

Medicines radiolabeled with lutetium (177Lu) chloride must not be used in women unless pregnancy has been ruled out.[1]

History

Lutetium (177Lu) chloride was approved for use in the European Union in June 2015.[1]

References

"Lumark EPAR". European Medicines Agency. 17 September 2018. Retrieved 7 May 2020. This article incorporates text from this source, which is in the public domain.
"EndolucinBeta EPAR". European Medicines Agency (EMA). Retrieved 7 May 2020. This article incorporates text from this source, which is in the public domain.

External links

"Lutetium chloride Lu-177". Drug Information Portal. U.S. National Library of Medicine.

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[Lumark_EPAR-1] "Lumark EPAR". European Medicines Agency. 17 September 2018. Retrieved 7 May 2020. This article incorporates text from this source, which is in the public domain.

[EndolucinBeta_EPAR-2] "EndolucinBeta EPAR". European Medicines Agency (EMA). Retrieved 7 May 2020. This article incorporates text from this source, which is in the public domain.