Lugdunin
Lugdunin is an investigational antibiotic, classified as a thiazolidine-containing cyclic peptide. It was isolated in 2016 after Staphylococcus lugdunensis was identified as the species of bacteria from the human nose that suppressed growth of species of disease-causing bacteria in that part of the human microbiome.[1][2][3]
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IUPAC name
(1R,4R,7S,10R,13S,16R,19S)-7-(1H-Indol-3-ylmethyl)-10-isobutyl-4,13,16,19-tetraisopropyl-21-thia-3,6,9,12,15,18,23-heptaazabicyclo[18.2.1]tricosane-2,5,8,11,14,17-hexone | |
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Properties | |
C40H62N8O6S | |
Molar mass | 783.05 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Infobox references | |
Lugdunin is a non-ribosomally synthesized cyclic peptide that inhibits growth of Staphylococcus aureus strains. The lugdunin genes are located on a 30-kbp operon. The genes lugA, lugB, lugC, and lugD encode four non-ribosomal peptide synthases, which are preceded by a putative regulator gene lugR.[4]
Gene | locustag | protein size/aa | Genbank protein entry | RefSeq protein entry |
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lugR | SLUG_RS03935 | 196 | CCB53263.1 | WP_002460032.1 |
lugA | SLUG_RS03940 | 2374 | CCB53264.1 | WP_002478842.1 |
SLUG_RS03945 | 124 | CCB53265.1 | WP_002460029.1 | |
lugB | SLUG_RS03950 | 1230 | CCB53266.1 | WP_014533237.1 |
lugC | SLUG_RS03955 | 2937 | CCB53267.1 | WP_002478844.1 |
lugT | SLUG_RS03960 | 228 | CCB53268.1 | WP_002460022.1 |
lugD | SLUG_RS03965 | 579 | CCB53269.1 | WP_002478846.1 |
References
- Gallagher, James (2016-07-27). "Antibiotic resistance: 'Snot wars' study heralds new class of drugs". BBC News. Retrieved 2016-07-27.
- Zipperer, Alexander; Konnerth, Martin C.; Laux, Claudia; Berscheid, Anne; Janek, Daniela; Weidenmaier, Christopher; Burian, Marc; Schilling, Nadine A.; Slavetinsky, Christoph (2016). "Human commensals producing a novel antibiotic impair pathogen colonization". Nature. 535 (7613): 511–516. Bibcode:2016Natur.535..511Z. doi:10.1038/nature18634. PMID 27466123.
- "Scientists find microbiotic treasure hidden in the nose". latimes.com. Los Angeles Times. 2016-07-27. Retrieved 2016-07-27.
- Krismer, Bernhard; Peschel, Andreas; Grond, Stephanie; Brötz-Oesterhelt, Heike; Schittek, Birgit; Kalbacher, Hubert; Willmann, Matthias; Marschal, Matthias; Slavetinsky, Christoph; Schilling, Nadine A.; Burian, Marc; Weidenmaier, Christopher; Janek, Daniela; Berscheid, Anne; Laux, Claudia; Konnerth, Martin C.; Zipperer, Alexander (July 2016). "Extended Data Figure 1: Gene cluster of lugdunin and generation of S. lugdunensis IVK28-Xyl". Nature. 535 (7613): 511–516. Bibcode:2016Natur.535..511Z. doi:10.1038/nature18634. PMID 27466123.
External links
- "Press release: A potential lifesaver lies unrecognized in the human body" (PDF). www.uni-tuebingen.de. University of Tübingen. Retrieved 2016-07-28.
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