Low complexity regions in proteins

Low complexity regions in protein sequences (LCRs), also defined in some contexts as compositionally biased regions (CBRs), are regions in protein sequences that differ from the composition and complexity of most proteins that is normally associated with globular structure [1]. LCRs have different properties from normal regions regarding structure, function and evolution.

Detection methods
Main article: List of software to detect low complexity regions in proteins

Low complexity regions in proteins can be computionally detected from sequence using various methods and definitions.

gollark: I mean, your user thing says "Herbert West".
gollark: Next terrible idea: laser toast engraver.
gollark: I use plutonium to heat up my toaster, it saves so much electricity and only occasionally sets fire to toast.
gollark: Then you might get banned by Discord itself.
gollark: Technically, you can, if you annoy enough people that you're banned.

References
  1. Mier P, Paladin L, Tamana S, Petrosian S, Hajdu-Soltész B, Urbanek A, Gruca A, Plewczynski D, Grynberg M, Bernadó P, Gáspári Z, Ouzounis CA, Promponas VJ, Kajava AV, Hancock JM, Tosatto SC, Dosztanyi Z, Andrade-Navarro MA (30 January 2019). "Disentangling the complexity of low complexity proteins". Brief Bioinform. doi:10.1093/bib/bbz007. PMID 30698641.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.