Louis Pillemer

Louis Pillemer (1908 - August 31, 1957), was an American immunologist, an early investigator of the alternative complement pathway (a system of defense not dependent upon antibodies.)

Biography

Pillemer was born in Johannesburg, South Africa, in 1908, the son of Lithuanian parents. He was brought to the United States at the age of one year, and was naturalized in 1916. He attended public schools in Catlettsburg and Ashland, Kentucky, and began collegiate work at Ohio State University in Columbus, Ohio, later attending Marshall College at Huntington, West Virginia, and Duke University at Durham, North Carolina. At Duke he received a B.S. degree in 1932, and also completed two years in medicine.

Found dead at his home in Cleveland Heights, Ohio, at the age of 49 years. His death was ruled a suicide. He was survived by a wife and four young sons.[1]

Discoveries

He led a team at Western Reserve University which discovered properdin in 1954,[2] and this discovery received attention from the national press as a breakthorough in immunology.[3]

In 1957, Robert Nelson challenged these findings, and claimed that Pillemer's results were due to laboratory errors.[4] Pillemer's death soon after publications was ruled a suicide.

Nelson's view prevailed at the time, but further study in the 1960s largely led to a confirmation of much of Pillemer's work.[5][6]

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References
  1. http://www.jimmunol.org/content/80/6/414.short
  2. PILLEMER L, BLUM L, LEPOW I, ROSS O, TODD E, WARDLAW A (1954). "The properdin system and immunity. I. Demonstration and isolation of a new serum protein, properdin, and its role in immune phenomena". Science. 120 (3112): 279–85. doi:10.1126/science.120.3112.279. PMID 13186838.
  3. "Medicine: Death to Germs". Time. September 13, 1954. Retrieved May 11, 2010.
  4. Nelson R (1958). "An alternative mechanism for the properdin system". J. Exp. Med. 108 (4): 515–35. doi:10.1084/jem.108.4.515. PMC 2136897. PMID 13575682.
  5. Lepow I (1980). "Presidential address to American Association of Immunologists in Anaheim, California, April 16, 1980. Louis Pillemer, Properdin, and scientific controversy". J. Immunol. 125 (2): 471–5. PMID 6993558.
  6. Some of his works are referenced here : http://www.nature.com/nature/journal/v181/n4604/abs/181234b0.html



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