Loon (monkey)

Loon (September 16, 1979[1] – June 17, 2003) was a drill in the San Diego Zoo. He was trained to accept regular blood sampling and insulin injection in order to treat his diabetes mellitus.

Life
Loon having blood drawn from his arm.

Loon was born in the Philadelphia Zoo in 1979,[2] and transferred to the San Diego Zoo in 1982.[3] He was named "Loon" because of his vocalizations.[2]

In June 1989, Loon began rapidly losing weight, and in July of that year he was diagnosed with diabetes.[3] Treatment began immediately, with multiple daily blood draws and insulin injections; however, this led Loon to become extremely aggressive, and the zoo was forced to restrain him in a small cage, and to sedate him before procedures. As a result, he developed neurotic and stereotyped behavior, which decreased his quality of life so much that euthanasia was considered.[3][4]

With the help of a former SeaWorld animal trainer,[5] zoo personnel used operant conditioning techniques so that Loon would associate venipuncture and other medical procedures with rewards such as getting fed or groomed. He subsequently learned to participate in getting himself weighed,[3] and to provide daily urine samples by "go[ing] potty" on command.[4]

Loon eventually became a role model for human children with diabetes who were likewise reluctant to receive multiple injections,[4] and the techniques which had been used to train him were adapted by other institutions to train their animals to accede to medical procedures.[2]

Legacy

Samples of Loon's tissues have been cryopreserved in a frozen zoo.[4][6] Due to physical consequences of his diabetes, Loon was unable to breed naturally;[6] however, his semen was assigned to the Columbus Zoo, where female drills are available for artificial insemination.[4] As well, he was one of the first two animals of an endangered species to have his tissue samples used to make induced pluripotent stem cells as an attempt at conservation.[1][7][1][8]

gollark: I agree. Existing problems probably require more people to think of clever ideas and such.
gollark: Of course, in case of catastrophic societal implosion, people will just flock to the copy of Wikipedia I etched into some unused mountains.
gollark: In case of catastrophic societal implosion and people somehow using it.
gollark: Nobody will pay attention to that kind of vague platitude. At most it would be used for calendrical functions probably.
gollark: Well, if you're good at faking things and the organization is sufficiently dysfunctional, things.

References
  1. Ben-Nun IF, Montague SC, Houck ML, Tran HT, Garitaonandia I, Leonardo TR, Wang YC, Charter SJ, Laurent LC, Ryder OA, Loring JF (2011). "Induced pluripotent stem cells from highly endangered species" (PDF). Nature Methods. 8 (10): 829–31. doi:10.1038/nmeth.1706. PMID 21892153.
  2. Zoo farewells pioneering monkey, at the Australian Broadcasting Corporation; published June 16, 2003; retrieved June 14, 2016
  3. Training a Diabetic Drill (Mandrillus leucophaeus) to Accept Insulin Injections and Venipuncture, by Gary Priest, in Laboratory Primate Newsletter; volume 30, number 1 January 1991; archived at Brown University; retrieved June 14, 2016
  4. End of life near for pioneering monkey at zoo, by James Steinberg, in the San Diego Union-Tribune; published June 16, 2003; retrieved June 14, 2016
  5. Kicked, Bitten, and Scratched: Life and Lessons at the World's Premier School for Exotic Animal Trainers, by Amy Sutherland; published 2006, by Penguin Books
  6. NEW TECHNOLOGIES HELP RARE ANIMALS REPRODUCE, by Michele Ostrove, in Deseret News; published March 18, 1990; retrieved June 14, 2016
  7. Stem cell research could save endangered rhinos and monkeys, by Janet Fang; at ZDNet; published September 7, 2011; retrieved June 14, 2016
  8. Ben-Nun IF, Montague SC, Houck ML, Ryder O, Loring JF (2015). Generation of Induced Pluripotent Stem Cells from Mammalian Endangered Species. Methods in Molecular Biology. 1330. pp. 101–9. doi:10.1007/978-1-4939-2848-4_10. ISBN 978-1-4939-2847-7. PMID 26621593.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.