Leukoencephalopathy with neuroaxonal spheroids
Leukoencephalopathy with neuroaxonal spheroids is a special kind of leukoencephalopathy. It is a cause of severe and subacute dementia. It is inherited, following an autosomal dominant pattern.
| Leukoencephalopathy with neuroaxonal spheroids | |
|---|---|
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| This condition is inherited in an autosomal dominant manner | |
| Specialty | Neurology |
It usually presents in childhood but it can also have an adult onset,[1] in which case it can present MRIs that mimic those of progressive multiple sclerosis.[2]
See also
References
- Adams SJ, Kirk A, Auer RN (2018). "Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP): Integrating the literature on hereditary diffuse leukoencephalopathy with spheroids (HDLS) and pigmentary orthochromatic leukodystrophy (POLD)". Journal of Clinical Neuroscience. 48 (1): 42–49. doi:10.1016/j.jocn.2017.10.060. PMID 29122458.
- Keegan BM, Giannini C, Parisi JE, Lucchinetti CF, Boeve BF, Josephs KA (March 2008). "Sporadic adult-onset leukoencephalopathy with neuroaxonal spheroids mimicking cerebral MS". Neurology. 70 (13 Pt 2): 1128–33. doi:10.1212/01.wnl.0000304045.99153.8f. PMID 18287567.
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