Layilin
Layilin is a protein that in humans is encoded by the LAYN gene.[5]
| LAYN | |||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||
| Aliases | LAYN, Layilin | ||||||||||||||||||||||||
| External IDs | MGI: 2685357 HomoloGene: 18716 GeneCards: LAYN | ||||||||||||||||||||||||
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| Orthologs | |||||||||||||||||||||||||
| Species | Human | Mouse | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
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| RefSeq (mRNA) | |||||||||||||||||||||||||
| RefSeq (protein) | |||||||||||||||||||||||||
| Location (UCSC) | Chr 11: 111.54 – 111.56 Mb | Chr 9: 51.05 – 51.08 Mb | |||||||||||||||||||||||
| PubMed search | [3] | [4] | |||||||||||||||||||||||
| Wikidata | |||||||||||||||||||||||||
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Medical Relevance
A study has shown that Layilin is upregulated in tumor infiltrating CD8+ Cytotoxic T cells of patients with liver cancer.[6]
gollark: It does - except skynet2 because weirdness - work. I just don't know what's going on with whatever you complained about; perhaps events being eaten?
gollark: Anyway, I would investigate the skynet desyncs problem, except I have no idea where to start or what could be doing it.
gollark: ncurses
gollark: What's the use of minificatinizing that?
gollark: Since it has to connect to my external server, and the event system is really weird in CC, it's kind of hard to get real-time communications working well with it.
References
- GRCh38: Ensembl release 89: ENSG00000204381 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000060594 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Layilin".
- Zheng C, Zheng L, Yoo JK, Guo H, Zhang Y, Guo X, Kang B, Hu R, Huang JY, Zhang Q, Liu Z, Dong M, Hu X, Ouyang W, Peng J, Zhang Z (2017). "Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing". Cell. 169 (7): 1342–1356.e16. doi:10.1016/j.cell.2017.05.035. PMID 28622514.
Further reading
- Bono P, Rubin K, Higgins JM, Hynes RO (2001). "Layilin, a novel integral membrane protein, is a hyaluronan receptor". Mol. Biol. Cell. 12 (4): 891–900. doi:10.1091/mbc.12.4.891. PMC 32274. PMID 11294894.
- Borowsky ML, Hynes RO (1998). "Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles". J. Cell Biol. 143 (2): 429–42. doi:10.1083/jcb.143.2.429. PMC 2132847. PMID 9786953.
- Forteza RM, Casalino-Matsuda SM, Falcon NS, Valencia Gattas M, Monzon ME (2012). "Hyaluronan and layilin mediate loss of airway epithelial barrier function induced by cigarette smoke by decreasing E-cadherin". J. Biol. Chem. 287 (50): 42288–98. doi:10.1074/jbc.M112.387795. PMC 3516772. PMID 23048036.
- Bono P, Cordero E, Johnson K, Borowsky M, Ramesh V, Jacks T, Hynes RO (2005). "Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin". Exp. Cell Res. 308 (1): 177–87. doi:10.1016/j.yexcr.2005.04.017. PMID 15913605.
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