LTBP3

Latent-transforming growth factor beta-binding protein 3 is a protein that in humans is encoded by the LTBP3 gene.[5][6]

LTBP3
Identifiers
Aliases	LTBP3, LTBP-3, LTBP2, STHAG6, pp6425, DASS, latent transforming growth factor beta binding protein 3, GPHYSD3
External IDs	OMIM: 602090 MGI: 1101355 HomoloGene: 7405 GeneCards: LTBP3
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,538,805 bp[1] End 65,558,930 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 4.34 cM Start 5,740,904 bp[2] End 5,758,532 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • transforming growth factor beta binding • growth factor binding Cellular component • extracellular matrix • extracellular exosome • extracellular region • collagen-containing extracellular matrix Biological process • transforming growth factor beta activation • positive regulation of mesenchymal stem cell proliferation • positive regulation of mesenchymal stem cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4054	16998
Ensembl	ENSG00000168056	ENSMUSG00000024940
UniProt	Q9NS15	Q61810
RefSeq (mRNA)	NM_001130144 NM_001164266 NM_021070	NM_008520
RefSeq (protein)	NP_001123616 NP_001157738 NP_066548	NP_032546
Location (UCSC)	Chr 11: 65.54 – 65.56 Mb	Chr 19: 5.74 – 5.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000168056 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024940 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Li X, Yin W, Perez-Jurado L, Bonadio J, Francke U (May 1995). "Mapping of human and murine genes for latent TGF-beta binding protein-2 (LTBP2)" (PDF). Mamm Genome. 6 (1): 42–5. doi:10.1007/BF00350892. PMID 7719025.
6. "Entrez Gene: LTBP3 latent transforming growth factor beta binding protein 3".

Further reading

• Saharinen J, Hyytiäinen M, Taipale J, Keski-Oja J (2000). "Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action". Cytokine Growth Factor Rev. 10 (2): 99–117. doi:10.1016/S1359-6101(99)00010-6. PMID 10743502.
• Oklü R, Hesketh R (2001). "The latent transforming growth factor beta binding protein (LTBP) family". Biochem. J. 352 Pt 3 (Pt 3): 601–10. doi:10.1042/0264-6021:3520601. PMC 1221494. PMID 11104663.
• Morén A, Olofsson A, Stenman G, et al. (1995). "Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein". J. Biol. Chem. 269 (51): 32469–78. PMID 7798248.
• Michel K, Roth S, Trautwein C, et al. (1998). "Analysis of the expression pattern of the latent transforming growth factor beta binding protein isoforms in normal and diseased human liver reveals a new splice variant missing the proteinase-sensitive hinge region". Hepatology. 27 (6): 1592–9. doi:10.1002/hep.510270619. PMID 9620332.
• Saharinen J, Keski-Oja J (2000). "Specific Sequence Motif of 8-Cys Repeats of TGF-β Binding Proteins, LTBPs, Creates a Hydrophobic Interaction Surface for Binding of Small Latent TGF-β". Mol. Biol. Cell. 11 (8): 2691–704. doi:10.1091/mbc.11.8.2691. PMC 14949. PMID 10930463.
• Brooke JS, Cha JH, Eidels L (2002). "Latent transforming growth factor β-binding protein-3 and fibulin-1C interact with the extracellular domain of the heparin-binding EGF-like growth factor precursor". BMC Cell Biol. 3: 2. doi:10.1186/1471-2121-3-2. PMC 65547. PMID 11846885.
• Chen Y, Dabovic B, Annes JP, Rifkin DB (2002). "Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion". FEBS Lett. 517 (1–3): 277–80. doi:10.1016/S0014-5793(02)02648-0. PMID 12062452.
• Penttinen C, Saharinen J, Weikkolainen K, et al. (2003). "Secretion of human latent TGF-beta-binding protein-3 (LTBP-3) is dependent on co-expression of TGF-beta". J. Cell Sci. 115 (Pt 17): 3457–68. PMID 12154076.
• Ludbrook SB, Barry ST, Delves CJ, Horgan CM (2003). "The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3". Biochem. J. 369 (Pt 2): 311–8. doi:10.1042/BJ20020809. PMC 1223078. PMID 12358597.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Koli K, Hyytiäinen M, Ryynänen MJ, Keski-Oja J (2005). "Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts". Exp. Cell Res. 310 (2): 370–82. doi:10.1016/j.yexcr.2005.08.008. PMID 16157329.
• Kantola AK, Keski-Oja J, Koli K (2006). "Induction of human LTBP-3 promoter activity by TGF-beta1 is mediated by Smad3/4 and AP-1 binding elements". Gene. 363: 142–50. doi:10.1016/j.gene.2005.07.042. PMID 16223572.