LRRN2

Leucine-rich repeat neuronal protein 2 is a protein that in humans is encoded by the LRRN2 gene.[5][6]

LRRN2
Identifiers
Aliases	LRRN2, FIGLER7, GAC1, LRANK1, LRRN5, leucine rich repeat neuronal 2
External IDs	OMIM: 605492 MGI: 106037 HomoloGene: 21274 GeneCards: LRRN2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 204,617,170 bp[1] End 204,685,738 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 132,880,273 bp[2] End 132,940,005 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • signaling receptor activity Cellular component • integral component of membrane • membrane • extracellular • extracellular matrix Biological process • cell adhesion • axonogenesis • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10446	16980
Ensembl	ENSG00000170382	ENSMUSG00000026443
UniProt	O75325	Q6PHP6
RefSeq (mRNA)	NM_006338 NM_201630	NM_010732
RefSeq (protein)	NP_006329 NP_963924	NP_034862
Location (UCSC)	Chr 1: 204.62 – 204.69 Mb	Chr 1: 132.88 – 132.94 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000170382 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026443 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Almeida A, Zhu XX, Vogt N, Tyagi R, Muleris M, Dutrillaux AM, Dutrillaux B, Ross D, Malfoy B, Hanash S (Aug 1998). "GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas". Oncogene. 16 (23): 2997–3002. doi:10.1038/sj.onc.1201828. PMID 9662332.
6. "Entrez Gene: LRRN2 leucine rich repeat neuronal 2".

Further reading

• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Adams MD, Soares MB, Kerlavage AR, et al. (1993). "Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library". Nat. Genet. 4 (4): 373–80. doi:10.1038/ng0893-373. PMID 8401585.