LRRK1

Leucine-rich repeat serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the LRRK1 gene.[5][6][7]

LRRK1
Identifiers
Aliases	LRRK1, RIPK6, Roco1, leucine-rich repeat kinase 1, leucine rich repeat kinase 1
External IDs	OMIM: 610986 MGI: 2142227 HomoloGene: 23464 GeneCards: LRRK1
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.3 Start 100,919,327 bp[1] End 101,078,257 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 C Start 66,226,912 bp[2] End 66,388,350 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • kinase activity • transferase activity • nucleotide binding • protein kinase activity • GTP binding • GO:0001948 protein binding • ATP binding • metal ion binding • identical protein binding • protein serine/threonine kinase activity • signal transducer activity Cellular component • mitochondrion • cytoplasm • cytosol Biological process • positive regulation of canonical Wnt signaling pathway • osteoclast development • negative regulation of peptidyl-tyrosine phosphorylation • GO:0010740 positive regulation of intracellular signal transduction • bone resorption • phosphorylation • positive regulation of peptidyl-tyrosine phosphorylation • GO:0007243 intracellular signal transduction • protein phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79705	233328
Ensembl	ENSG00000154237	ENSMUSG00000015133
UniProt	Q38SD2	Q3UHC2
RefSeq (mRNA)	NM_024652	NM_146191
RefSeq (protein)	NP_078928	NP_666303
Location (UCSC)	Chr 15: 100.92 – 101.08 Mb	Chr 7: 66.23 – 66.39 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000154237 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015133 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (May 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
6. Bosgraaf L, Van Haastert PJ (Dec 2003). "Roc, a Ras/GTPase domain in complex proteins". Biochim Biophys Acta. 1643 (1–3): 5–10. doi:10.1016/j.bbamcr.2003.08.008. PMID 14654223.
7. "Entrez Gene: LRRK1 leucine-rich repeat kinase 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Korr D, Toschi L, Donner P, et al. (2006). "LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain". Cell. Signal. 18 (6): 910–20. doi:10.1016/j.cellsig.2005.08.015. PMID 16243488.
• Zody MC, Garber M, Sharpe T, et al. (2006). "Analysis of the DNA sequence and duplication history of human chromosome 15". Nature. 440 (7084): 671–5. doi:10.1038/nature04601. PMID 16572171.
• Haugarvoll K, Toft M, Ross OA, et al. (2007). "Variants in the LRRK1 gene and susceptibility to Parkinson's disease in Norway". Neurosci. Lett. 416 (3): 299–301. doi:10.1016/j.neulet.2007.02.020. PMID 17324517.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Greggio E, Lewis PA, van der Brug MP, et al. (2007). "Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1". J. Neurochem. 102 (1): 93–102. doi:10.1111/j.1471-4159.2007.04523.x. PMID 17394548.