LRRFIP1

Leucine-rich repeat flightless-interacting protein 1 is a protein that in humans is encoded by the LRRFIP1 gene.[5][6][7][8]

LRRFIP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4H22
Identifiers
Aliases	LRRFIP1, FLAP-1, FLAP1, FLIIAP1, GCF-2, GCF2, HUFI-1, TRIP, leucine rich repeat (in FLII) interacting protein 1, LRR binding FLII interacting protein 1
External IDs	OMIM: 603256 MGI: 1342770 HomoloGene: 48301 GeneCards: LRRFIP1
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 237,627,587 bp[1] End 237,813,682 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 90,998,737 bp[2] End 91,128,944 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • double-stranded RNA binding • GO:0001948 protein binding • protein homodimerization activity • cadherin binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell membrane • cytoskeleton • cell nucleus • cytoplasm • cytosol Biological process • regulation of transcription from RNA polymerase II promoter • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • positive regulation of type I interferon production • transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • positive regulation of NF-kappaB transcription factor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9208	16978
Ensembl	ENSG00000124831	ENSMUSG00000026305
UniProt	Q32MZ4	Q3UZ39
RefSeq (mRNA)	NM_001137550 NM_001137551 NM_001137552 NM_001137553 NM_004735	NM_001111311 NM_001111312 NM_008515 NM_001310732
RefSeq (protein)	NP_001131022 NP_001131023 NP_001131024 NP_001131025 NP_004726	NP_001104781 NP_001104782 NP_001297661 NP_032541
Location (UCSC)	Chr 2: 237.63 – 237.81 Mb	Chr 1: 91 – 91.13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

LRRFIP1 has been shown to interact with FLII.[6][9]

References

1. GRCh38: Ensembl release 89: ENSG00000124831 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026305 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Reed AL, Yamazaki H, Kaufman JD, Rubinstein Y, Murphy B, Johnson AC (Sep 1998). "Molecular cloning and characterization of a transcription regulator with homology to GC-binding factor". J Biol Chem. 273 (34): 21594–602. doi:10.1074/jbc.273.34.21594. PMID 9705290.
6. Liu YT, Yin HL (May 1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J Biol Chem. 273 (14): 7920–7. doi:10.1074/jbc.273.14.7920. PMID 9525888.
7. Suriano AR, Sanford AN, Kim N, Oh M, Kennedy S, Henderson MJ, Dietzmann K, Sullivan KE (Oct 2005). "GCF2/LRRFIP1 represses tumor necrosis factor alpha expression". Mol Cell Biol. 25 (20): 9073–81. doi:10.1128/MCB.25.20.9073-9081.2005. PMC 1265793. PMID 16199883.
8. "Entrez Gene: LRRFIP1 leucine rich repeat (in FLII) interacting protein 1".
9. Fong KS, de Couet HG (Jun 1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. PMID 10366446.

Further reading

• Wilson SA, Brown EC, Kingsman AJ, Kingsman SM (1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Res. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. PMC 147727. PMID 9671805.
• Khachigian LM, Santiago FS, Rafty LA, Chan OL, Delbridge GJ, Bobik A, Collins T, Johnson AC (1999). "GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury". Circ. Res. 84 (11): 1258–67. doi:10.1161/01.res.84.11.1258. PMID 10364563.
• Fong KS, de Couet HG (1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. PMID 10366446.
• Rikiyama T, Curtis J, Oikawa M, Zimonjic DB, Popescu N, Murphy BA, Wilson MA, Johnson AC (2003). "GCF2: expression and molecular analysis of repression". Biochim. Biophys. Acta. 1629 (1–3): 15–25. doi:10.1016/s0167-4781(03)00156-8. PMID 14522076.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.