LOC642658

SCX
Identifiers
Aliases	SCX, SCXA, SCXB, bHLHa48, LOC642658, scleraxis bHLH transcription factor
External IDs	OMIM: 609067 MGI: 102934 HomoloGene: 85195 GeneCards: SCX
Gene location (Human)
Chr.	Chromosome 8 (human)[1]
End	144,268,481 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	76,459,458 bp[2]
Gene ontology
Molecular function	• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • DNA binding; • sequence-specific DNA binding; • protein dimerization activity; • bHLH transcription factor binding; • E-box binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • protein heterodimerization activity; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	• transcription factor complex; • cell nucleus;
Biological process	• cellular response to transforming growth factor beta stimulus; • positive regulation of collagen biosynthetic process; • cell differentiation; • regulation of transcription, DNA-templated; • chondrocyte differentiation; • regulation of cartilage development; • positive regulation of gastrulation; • collagen fibril organization; • tendon development; • tendon cell differentiation; • mesoderm formation; • cellular response to BMP stimulus; • negative regulation of apoptotic process; • Sertoli cell differentiation; • endochondral ossification; • transcription from RNA polymerase II promoter; • BMP signaling pathway; • transcription, DNA-templated; • sclerotome development; • embryonic skeletal system development; • positive regulation of transcription, DNA-templated; • multicellular organism development; • deltoid tuberosity development; • cellular response to mechanical stimulus; • positive regulation of gene expression; • heart valve formation; • positive regulation of cartilage development; • heart valve morphogenesis; • tissue homeostasis; • positive regulation of cell proliferation; • tendon formation; • skeletal muscle cell differentiation; • negative regulation of transcription, DNA-templated; • face morphogenesis; • positive regulation of transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	642658
	20289
	ENSG00000260428
	ENSMUSG00000034161
	Q7RTU7
	Q64124
	NM_001008271; NM_001080514
	NM_198885
	NP_001073983
	NP_942588
	Wikidata
View/Edit Human	View/Edit Mouse

Basic helix-loop-helix transcription factor scleraxis is a protein that in humans is encoded by the SCXB gene.[5]

References

GRCh38: Ensembl release 89: ENSG00000260428 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000034161 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: LOC642658 similar to Basic helix-loop-helix transcription factor scleraxis".

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000260428 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034161 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: LOC642658 similar to Basic helix-loop-helix transcription factor scleraxis".