LIN9

Lin-9 homolog is a protein that is encoded by the LIN9 gene in humans.[5][6]

LIN9
Identifiers
Aliases	LIN9, BARA, BARPsv, Lin-9, TGS, TGS1, TGS2, lin-9 DREAM MuvB core complex component
External IDs	OMIM: 609375 MGI: 1919818 HomoloGene: 35252 GeneCards: LIN9
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.12 Start 226,231,149 bp[1] End 226,309,869 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H4 Start 180,641,150 bp[2] End 180,690,694 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • DNA binding Cellular component • transcriptional repressor complex • cell nucleus • nucleoplasm Biological process • cell cycle • DNA biosynthetic process • transcription, DNA-templated • regulation of cell cycle • reproduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	286826	72568
Ensembl	ENSG00000183814	ENSMUSG00000058729
UniProt	Q5TKA1	Q8C735
RefSeq (mRNA)	NM_001270409 NM_001270410 NM_173083 NM_001366237 NM_001366238 NM_001366239 NM_001366240 NM_001366241 NM_001366245	NM_001103182 NM_175186
RefSeq (protein)	NP_001257338 NP_001257339 NP_775106 NP_001353166 NP_001353167 NP_001353168 NP_001353169 NP_001353170 NP_001353174	n/a
Location (UCSC)	Chr 1: 226.23 – 226.31 Mb	Chr 1: 180.64 – 180.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

LIN9 has been shown to interact with the retinoblastoma protein.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000183814 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058729 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gagrica S, Hauser S, Kolfschoten I, Osterloh L, Agami R, Gaubatz S (Nov 2004). "Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein". The EMBO Journal. 23 (23): 4627–38. doi:10.1038/sj.emboj.7600470. PMC 533054. PMID 15538385.
6. "Entrez Gene: LIN9 lin-9 homolog (C. elegans)".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Korenjak M, Taylor-Harding B, Binné UK, Satterlee JS, Stevaux O, Aasland R, White-Cooper H, Dyson N, Brehm A (Oct 2004). "Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes". Cell. 119 (2): 181–93. doi:10.1016/j.cell.2004.09.034. PMID 15479636.
• Sandoval R, Xue J, Tian X, Barrett K, Pilkinton M, Ucker DS, Raychaudhuri P, Kineman RD, Luque RM, Baida G, Zou X, Valli VE, Cook JL, Kiyokawa H, Colamonici OR (Aug 2006). "A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by releasing the repression on E2F-regulated genes". Experimental Cell Research. 312 (13): 2465–75. doi:10.1016/j.yexcr.2006.04.002. PMID 16730350.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Pilkinton M, Sandoval R, Song J, Ness SA, Colamonici OR (Jan 2007). "Mip/LIN-9 regulates the expression of B-Myb and the induction of cyclin A, cyclin B, and CDK1". The Journal of Biological Chemistry. 282 (1): 168–75. doi:10.1074/jbc.M609924200. PMID 17098733.
• Osterloh L, von Eyss B, Schmit F, Rein L, Hübner D, Samans B, Hauser S, Gaubatz S (Jan 2007). "The human synMuv-like protein LIN-9 is required for transcription of G2/M genes and for entry into mitosis". The EMBO Journal. 26 (1): 144–57. doi:10.1038/sj.emboj.7601478. PMC 1782375. PMID 17159899.
• Pilkinton M, Sandoval R, Colamonici OR (Nov 2007). "Mammalian Mip/LIN-9 interacts with either the p107, p130/E2F4 repressor complex or B-Myb in a cell cycle-phase-dependent context distinct from the Drosophila dREAM complex". Oncogene. 26 (54): 7535–43. doi:10.1038/sj.onc.1210562. PMID 17563750.