LDB2

LIM domain-binding protein 2 is a protein that in humans is encoded by the LDB2 gene.[5][6][7][8]

LDB2
Identifiers
Aliases	LDB2, CLIM1, LDB1, LDB-2, LIM domain binding 2
External IDs	OMIM: 603450 MGI: 894670 HomoloGene: 989 GeneCards: LDB2
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p15.32 Start 16,501,541 bp[1] End 16,898,678 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B3 Start 44,472,132 bp[2] End 44,799,680 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • enzyme binding • LIM domain binding • GO:0001104 transcription cofactor activity • GO:0001948 protein binding • RNA polymerase II activating transcription factor binding Cellular component • cell nucleus • transcription factor complex • cell leading edge • nucleolus • cell membrane Biological process • regulation of transcription from RNA polymerase II promoter • hair follicle development • positive regulation of cellular component biogenesis • epithelial structure maintenance • somatic stem cell population maintenance • positive regulation of transcription from RNA polymerase II promoter • regulation of kinase activity • regulation of cell migration • negative regulation of transcription from RNA polymerase II promoter • multicellular organism development • negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9079	16826
Ensembl	ENSG00000169744	ENSMUSG00000039706
UniProt	O43679	O55203
RefSeq (mRNA)	NM_001130834 NM_001290 NM_001304434 NM_001304435	NM_001077398 NM_001286348 NM_010698 NM_001347349 NM_001359070 NM_001359071
RefSeq (protein)	NP_001124306 NP_001281 NP_001291363 NP_001291364	NP_001070866 NP_001273277 NP_001334278 NP_034828 NP_001345999 NP_001346000
Location (UCSC)	Chr 4: 16.5 – 16.9 Mb	Chr 5: 44.47 – 44.8 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000169744 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039706 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M (Feb 1999). "Selection system for genes encoding nuclear-targeted proteins". Nat Biotechnol. 16 (13): 1338–42. doi:10.1038/4315. PMID 9853615.
6. Retaux S, Rogard M, Bach I, Failli V, Besson MJ (Feb 1999). "Lhx9: a novel LIM-homeodomain gene expressed in the developing forebrain". J Neurosci. 19 (2): 783–93. PMID 9880598.
7. Kotaka M, Kostin S, Ngai S, Chan K, Lau Y, Lee SM, Li H, Ng EK, Schaper J, Tsui SK, Fung K, Lee C, Waye MM (Oct 2000). "Interaction of hCLIM1, an enigma family protein, with alpha-actinin 2". J Cell Biochem. 78 (4): 558–65. doi:10.1002/1097-4644(20000915)78:4<558::AID-JCB5>3.0.CO;2-I. PMID 10861853.
8. "Entrez Gene: LDB2 LIM domain binding 2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Semina EV, Altherr MR, Murray JC (1998). "Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI". Mamm. Genome. 9 (11): 921–4. doi:10.1007/s003359900899. PMID 9799849.
• Ueki N, Seki N, Yano K, et al. (1999). "Isolation and chromosomal assignment of human genes encoding cofactor of LIM homeodomain proteins, CLIM1 and CLIM2". J. Hum. Genet. 44 (2): 112–5. doi:10.1007/s100380050120. PMID 10083735.
• Bach I, Rodriguez-Esteban C, Carrière C, et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–9. doi:10.1038/11970. PMID 10431247.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.