LBH (gene)

Protein LBH is a protein that in humans is encoded by the LBH gene.[5][6][7]

LBH
Identifiers
Aliases	LBH, limb bud and heart development, LBH regulator of WNT signaling pathway
External IDs	OMIM: 611763 MGI: 1925139 HomoloGene: 12687 GeneCards: LBH
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.1 Start 30,231,534 bp[1] End 30,323,730 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E1.3 Start 72,918,305 bp[2] End 72,941,947 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • cell nucleus • macromolecular complex Biological process • multicellular organism development • positive regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • transcription, DNA-templated • mammary gland development • negative regulation of intracellular estrogen receptor signaling pathway • mammary gland epithelial cell differentiation • positive regulation of somatic stem cell population maintenance • positive regulation of somatic stem cell division • positive regulation of mammary stem cell proliferation • negative regulation of stem cell differentiation • regulation of gene expression • regulation of MAPK cascade • negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	81606	77889
Ensembl	ENSG00000213626	ENSMUSG00000024063
UniProt	Q53QV2	Q9CX60
RefSeq (mRNA)	NM_030915	NM_029999
RefSeq (protein)	NP_112177	NP_084275
Location (UCSC)	Chr 2: 30.23 – 30.32 Mb	Chr 17: 72.92 – 72.94 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000213626 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024063 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
6. Briegel KJ, Joyner AL (May 2001). "Identification and characterization of Lbh, a novel conserved nuclear protein expressed during early limb and heart development". Dev Biol. 233 (2): 291–304. doi:10.1006/dbio.2001.0225. PMID 11336496.
7. "Entrez Gene: LBH limb bud and heart development homolog (mouse)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Briegel KJ, Baldwin HS, Epstein JA, Joyner AL (2005). "Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh". Development. 132 (14): 3305–16. doi:10.1242/dev.01887. PMID 15958514.
• Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.