Krzysztof Palczewski

Krzysztof Palczewski is a Polish-American biochemist working at the University of California, Irvine. In 2012 he was awarded Prize of the Foundation for Polish Science, the most prestigious scientific award for Polish scientists, for characterizing crystal structures of native and activated G protein-coupled receptor, rhodopsin, involved in eyesight.[1]

Krzysztof Palczewski
Born1957
Syców, Poland
Alma materUniversity of Wrocław, Wrocław University of Technology
Known forRhodopsin
AwardsHumboldt Research Award
Prize of the Foundation for Polish Science (2012)[1]

ARVO Friedenwald award (2014) [2]
Beckman-Argyros award in Vision Research (2015)
Bressler Award in Vision Science (2015)[3]

Polish Academy of Arts and Sciences (2015, foreign member)
Marie Curie Medal (2017)
RRF Paul Kayser International Award in Retina Research (2018)

National Academy of Medicine (2019, member)
Scientific career
FieldsBiochemistry
InstitutionsCase Western Reserve University; University of California, Irvine
Doctoral advisorMarian Kochman
Website

His MS and PhD, are from the University of Wroclaw and Technical University of Wroclaw, respectively (Poland). His early posts were at the University of Florida and the Oregon Health Sciences University. Dr. Palczewski completed much of his pivotal research at the University of Washington. In 2005 he moved to become the Chair and John H. Hord professor of Pharmacology at Case Western Reserve University, where in 2016 he was appointed as Distinguished Professor of the Case Western Reserve University. In 2018 he joined University of California, Irvine, and is leading the Center for Translational Vision Research[4].

He is the founder of two drug discovery companies, Polgenix and Retinagenix.

Research interests

Palczewski's research interest lie in mapping the Visual Transduction System. His work with determining the crystal structure of rhodopsin has given new insight into the function of G protein receptors. Furthermore, his work on visual cycle has led to revolutionary advances in understanding hereditary blindness, leading to implementation of novel pharmacological treatments that can slow retinal degeneration in adults.[5][6] His team's latest efforts indicate that repetitive 2-photon imaging of the human eye can safely reveal the visual system's subcellular architecture and that humans can detect infrared light due to simultaneous 2-photon absorption. [7] [8]

gollark: It's pointless to say "I don't like this! Let's do it better" without any idea of what that would mean.
gollark: And ones which require some retroactive change like "let's all have become better at hygiene and gotten masks for everyone" or something obviously can't actually work.
gollark: If you have a better idea I'm sure someone will listen.
gollark: I mean, the UK initially went for an "ignore it and hope it goes away" sort of approach based on flawed modelling for flu, but then changed their strategy to the lockdown/social distancing one when updated models suggested this was a bad idea.
gollark: Like what? I'm pretty sure there has been thought about this.

References

Notes
  1. "Prof. Krzysztof Palczewski - FNP Prize 2012 laureate".
  2. Polans, Arthur S. (2014). "Introducing Krzysztof Palczewski, the 2014 Recipient of the Friedenwald Award". Investigative Ophthalmology & Visual Science. 55 (10): 6649–50. doi:10.1167/iovs.14-14843. PMID 25338685.
  3. "Lighthouse Guild | Bressler Prize in Vision Science Recipients".
  4. https://faculty.sites.uci.edu/ctvr/
  5. Jacobson, S. G.; Aleman, T. S.; Cideciyan, A. V.; Sumaroka, A.; Schwartz, S. B.; Windsor, E. A. M.; Traboulsi, E. I.; Heon, E.; Pittler, S. J.; Milam, A. H.; Maguire, A. M.; Palczewski, K.; Stone, E. M.; Bennett, J. (2005). "Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success". Proceedings of the National Academy of Sciences. 102 (17): 6177–6182. doi:10.1073/pnas.0500646102. PMC 1087926. PMID 15837919.
  6. Maeda, Akiko (2006). "Aberrant Metabolites in Mouse Models of Congenital Blinding Diseases: Formation and Storage of Retinyl Esters†". Biochemistry. 45 (13): 4210–4219. doi:10.1021/bi052382x. PMC 1560103. PMID 16566595.
  7. Palczewska, Grazyna; Dong, Zhiqian; Golczak, Marcin; Hunter, Jennifer J.; Williams, David R.; Alexander, Nathan S.; Palczewski, Krzysztof (2014). "Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye". Nature Medicine. 20 (7): 785–789. doi:10.1038/nm.3590. PMC 4087080. PMID 24952647.
  8. Palczewska, Grazyna; Vinberg, Frans; Stremplewski, Patrycjusz; Bircher, Martin P.; Salom, David; Komar, Katarzyna; Zhang, Jianye; Cascella, Michele; Wojtkowski, Maciej; Kefalov, Vladimir J.; Palczewski, Krzysztof (2014). "Human infrared vision is triggered by two-photon chromophore isomerization". Proceedings of the National Academy of Sciences. 111 (50): E5445–E5454. doi:10.1073/pnas.1410162111. PMC 4273384. PMID 25453064.

Bibliography
  • Vertebrate Phototransduction and the Visual Cycle, Krzysztof Palczewski, Academic Press (2000), ISBN 0-12-182217-6
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