Kosan Biosciences

Kosan Biosciences, Inc. (stock symbol: KOSN), is a pharmaceutical company which deals with cancer therapeutics medications. The company is currently working on advancing two new classes of anticancer agents through clinical development: heat shock protein 90 (Hsp90) inhibitors and epothilones.

Kosan Biosciences, Inc.
Founded1995
HeadquartersHayward, California
Key people
Helen S. Kim (President & CEO)
Number of employees
90
ParentBristol-Myers Squibb 

Their technology platform is based on manipulation of the genetic instructions of microbes for making natural product polyketides. Rearranging the modular units in natural polyketide synthases, combining modules from different enzymes, and incorporating novel synthetic chemical starter units enables them to produce a wide variety of novel polyketides that would be difficult to obtain via organic synthesis alone.[1]

Founded in 1995, Kosan is headquartered in Hayward, California and currently has approximately 90 employees. Kosan was funded in part as a venture capital start-up with funds from Sofinnova Ventures of California.

On June 26, 2008, Kosan Biosciences was acquired by Bristol-Myers Squibb.

Discodermolide

Discodermolide is a recently discovered polyketide natural product found to be a potent inhibitor of tumor cell growth. Kosan has been working in conjunction with the Amos B. Smith research group on a preclinical drug development program.

Management

Helen S. Kim is the President & CEO of Kosan Biosciences. One member of the Board of Directors, Dr. Jean Deleage, was one of the founders and managing partners of Burr, Egan, Deleage & Co., a private venture capital firm which invested in information technology, communications, and healthcare/biotechnology companies.

gollark: ```lua if settings.get "potatOS.removable" then potatOS.actually_really_uninstall = function(hedgehog) if hedgehog == "76fde5717a89e332513d4f1e5b36f6cb" then print "Hedgehog valid. Deleting potatOS main code." fs.delete "/autorun" else error "Invalid hedgehog! Expected 76fde5717a89e332513d4f1e5b36f6cb." end end end```Also this bit, optionally.
gollark: ```lua begin_uninstall_process = function() print "Please wait. Generating semiprime number..." local p1 = findprime(math.random(2, 100000)) local p2 = findprime(math.random(2, 100000)) local num = p1 * p2 print("Please find the prime factors of the following number:", num) write "Factor 1: " local f1 = tonumber(read()) write "Factor 2: " local f2 = tonumber(read()) if (f1 == p1 and f2 == p2) or (f2 == p1 and f1 == p2) then term.clear() term.setCursorPos(1, 1) print "Accepted. Moving startup." fs.delete "old-potatOS-startup" fs.move("startup", "old-potatOS-startup") print "Press any key to continue." os.pullEvent "key" os.reboot() else print("Factors", f1, f2, "invalid.", p1, p2, "expected.") end end```This bit is the uninstaller.
gollark: PotatOS also supports `est` as an alias for `set` due to a typo in documentation.
gollark: ```lua process.spawn(function() local signs = {peripheral.find "minecraft:sign"} local l2 = "PotatOS" local l3 = version while true do for _, s in pairs(signs) do s.setSignText("\167k" .. randbytes(16), l2, l3, "\167k" .. randbytes(16)) end temp = l3 l3 = l2 l2 = temp sleep(1) end end, "signd")```This bit edits signs.
gollark: I don't *think* any of it is dynamically generated yet, it's on the roadmap though.

References
  1. Menzella, H. G.; Carney, J. R.; Santi, D. V. (2007-02-01). "Rational Design and Assembly of Synthetic Trimodular Polyketide Synthases". Chemistry and Biology. 14 (2): 143–151. doi:10.1016/j.chembiol.2006.12.002. PMID 17317568.
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