Klaus Lauer

Dr. Klaus Lauer (born 1950) is a German neuroepidemologist, mostly known for his work on multiple sclerosis (MS).

Klaus Lauer

Early life

Klaus Joachim Lauer was born in 1950 and studied medicine in Frankfurt (Germany) from 1968 to 1975. He became a resident in the Department of Neurology of Klinikum Darmstadt, the Academic Teaching Hospital of Frankfurt University (Akademisches Lehrkrankenhaus der Universitäten Frankfurt/Main und Heidelberg-Mannheim, a major healthcare institution in South Hesse. Besides clinical work, K. Lauer devoted most of his research to epidemiology, with a special focus on MS etiology.

Career

Early on, he published a series of five articles[1][2][3][4][5] on multiple sclerosis in the land of Hesse with Prof. Dr. med. Wolfgang Firnhaber, who had already been studying MS epidemiology in Göttingen and Darmstadt,[6] with support from the Hertie Foundation, the German Research Foundation and the Stifterverband für die Deutsche Wissenschaft. His lasting collaboration with Prof. Firnhaber, a longtime expert in MS prognostication[7][8][9] and geomedical aspects of MS,[10] provided K. Lauer with a solid background in geomedical investigation.[11][12]

In the mid 80's, Dr. Lauer launched a series of specialized reports in Scandinavia, starting with a study of multiple sclerosis in Western Norway published in Neurology.[13] He has been following Norvegian MS ever since [14][15] and has also coauthored epidemiological studies in Sweden with Anne-Marie Landtblom and Inger Boström.[16]

Like John Kurtzke,[17] Klaus J. Lauer has dedicated a large part of his work to the study of MS in the Faroe Islands,[18] starting with a 1986 article in the Journal of Neurology entitled "Some comments on the occurrence of multiple sclerosis in the Faroe Islands",[19] followed in 1988 by "Multiple sclerosis in relation to industrial and commercial activities in the Faroe Islands"[20] in the journal Neuroepidemiology, followed one year later by "Dietary changes in temporal relation to multiple sclerosis in the Faroe Islands: an evaluation of literary sources"[21] in the same journal.

Remains of the WW2 British barracks at Vágar Airport on the Faroe Islands
2005 Faroese stamp: British soldiers and children in the Faroe Islands

MS is generally considered a multifactorial disease,[22] in which genetic predispositions and environmental triggers combine to launch an autoimmune process. As an international expert on the environmental dimension of MS,[23] Dr. Lauer compiled a review in Expert Review of Neurotherapeutics.[24]

Since 1992, Dr Lauer has published a large number of epidemiological studies covering most west European countries,[25][26][26][27][28][29] Russia,[30] the USA,[31][32] Canada, some countries in Asia and the Middle-East,[33] with a special focus on dietary aspects of etiology.[34][35][35][36][37] Most recently, Klaus Lauer has focused again on MS in the Faroes [38][39] and has been involved as an expert in the steering committee of the EnviMS study, a major multi-countries study investigating the impact of environmental exposures on MS.[40][41][42] Dr Lauer is also one of the authors of a reference study of the cost of MS in Europe[43] and of several publications dealing with technical and methodological considerations in neuroepidemiology applied to multiple sclerosis.[44][45]

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References
  1. Lauer K, Firnhaber W, Reining R, Leuchtweis B (October 1984). "Epidemiological investigations into multiple sclerosis in southern Hesse. I. Methodological problems and basic epidemiologic characteristics". Acta Neurologica Scandinavica. 70 (4): 257–65. doi:10.1111/j.1600-0404.1984.tb00823.x. PMID 6507035.
  2. Lauer K, Firnhaber W (October 1984). "Epidemiological investigations into multiple sclerosis in southern Hesse. II. The distribution of cases in relation to exogenous features". Acta Neurologica Scandinavica. 70 (4): 266–73. doi:10.1111/j.1600-0404.1984.tb00824.x. PMID 6507036.
  3. Lauer K, Firnhaber W (October 1985). "Epidemiological investigations into multiple sclerosis in Southern Hesse. III. The possible influence of occupation on the risk of disease". Acta Neurologica Scandinavica. 72 (4): 397–402. doi:10.1111/j.1600-0404.1985.tb00890.x. PMID 4082904.
  4. Lauer K, Firnhaber W (October 1985). "Epidemiological investigations into multiple sclerosis in Southern Hesse. IV. The influence of urban and rural environment on disease risk". Acta Neurologica Scandinavica. 72 (4): 403–6. doi:10.1111/j.1600-0404.1985.tb00891.x. PMID 4082905.
  5. Lauer K, Firnhaber W (July 1987). "Epidemiological investigations into multiple sclerosis in Southern Hesse. V. Course and prognosis". Acta Neurologica Scandinavica. 76 (1): 12–7. doi:10.1111/j.1600-0404.1987.tb03537.x. PMID 3498287.
  6. "Deutsches Ärzteblatt international: Multiple Sclerosis Registry in Germany – Results of the Extension Phase 2005/2006: Article of 30 Years Ago (25.04.2008)". Aerzteblatt.de. 2008-04-25. Retrieved 2015-04-01.
  7. Bauer HJ, Firnhaber W, Winkler W (March 1965). "Prognostic criteria in multiple sclerosis". Annals of the New York Academy of Sciences. 122 (1): 542–51. Bibcode:1965NYASA.122..542B. doi:10.1111/j.1749-6632.1965.tb20234.x. PMID 14313511.
  8. Bauer H, Firnhaber W (July 1963). "Zur Leistungsprognose Multiple-Sklerose-Kranker" [On the prognosis of work capacity in patients with multiple sclerosis]. Deutsche Medizinische Wochenschrift (in German). 88 (27): 1357–64. doi:10.1055/s-0028-1112108. PMID 13966928.
  9. Lauer K, Firnhaber W (February 1992). "Prognostic criteria in an epidemiological group of patients with multiple sclerosis: an exploratory study". Journal of Neurology. 239 (2): 93–7. doi:10.1007/BF00862981. PMID 1552310.
  10. Firnhaber W (May 1972). "[Multiple sclerosis. Methods and results of a geomedical study]". Fortschritte der Medizin (in German). 90 (14): 551–4. PMID 5072275.
  11. Poser S, Poser W, Schlaf G, et al. (November 1986). "Prognostic indicators in multiple sclerosis". Acta Neurologica Scandinavica. 74 (5): 387–92. doi:10.1111/j.1600-0404.1986.tb03531.x. PMID 3825497.
  12. Prange AJ, Lauer K, Poser S, et al. (1986). "Epidemiological aspects of multiple sclerosis: a comparative study of four centres in Europe". Neuroepidemiology. 5 (2): 71–9. doi:10.1159/000110816. PMID 3785525.
  13. Lauer K, Firnhaber W (September 1985). "Western Norway: a high-risk area for MS". Neurology. 35 (9): 1392. doi:10.1212/wnl.35.9.1392. PMID 4022391.
  14. Risberg G, Aarseth JH, Nyland H, Lauer K, Myhr KM, Midgard R (October 2011). "Prevalence and incidence of multiple sclerosis in Oppland County: a cross-sectional population-based study in a landlocked county of Eastern Norway". Acta Neurologica Scandinavica. 124 (4): 250–7. doi:10.1111/j.1600-0404.2010.01465.x. PMID 21143594.
  15. Lauer K (February 2006). "Multiple sclerosis in Nordland County". Tidsskrift for den Norske Lægeforening. 126 (5): 637–8. PMID 16505886.
  16. Boström I, Landtblom AM, Lauer K (December 2011). "An ecological study of industry in a high-risk region of multiple sclerosis". Journal of the Neurological Sciences. 311 (1–2): 50–7. doi:10.1016/j.jns.2011.09.005. PMID 21982618.
  17. "Multiple Sclerosis". Web.stanford.edu. 1997-03-21. Retrieved 2015-04-01.
  18. Klaus Lauer. "Dietary Changes in Temporal Relation to Multiple Sclerosis in the Faroe Islands : An Evaluation of Literary Sources" (PDF). While-science-sleeps.com. Retrieved 2015-04-01.
  19. Lauer K (June 1986). "Some comments on the occurrence of multiple sclerosis in the Faroe Islands". Journal of Neurology. 233 (3): 171–3. doi:10.1007/BF00314427. PMID 3522812.
  20. Lauer K (1988). "Multiple sclerosis in relation to industrial and commercial activities in the Faroe Islands". Neuroepidemiology. 7 (4): 228–33. doi:10.1159/000110155. PMID 3264057.
  21. Lauer K (1989). "Dietary changes in temporal relation to multiple sclerosis in the Faroe Islands: an evaluation of literary sources". Neuroepidemiology. 8 (4): 200–6. doi:10.1159/000110183. PMID 2755551.
  22. Amy Maxmen. "Whodunit? | Multiple Sclerosis Discovery Forum". Msdiscovery.org. Retrieved 2015-04-01.
  23. Lauer K (1995). "Environmental associations with the risk of multiple sclerosis: the contribution of ecological studies". Acta Neurologica Scandinavica. Supplementum. 161: 77–88. doi:10.1111/j.1600-0404.1995.tb05861.x. PMC 7159802. PMID 7653250.
  24. Lauer K (March 2010). "Environmental risk factors in multiple sclerosis". Expert Review of Neurotherapeutics. 10 (3): 421–40. doi:10.1586/ern.10.7. PMID 20187864.
  25. Lauer, K (1988). "Sociogeographic factors and multiple sclerosis--an ecological study in 6 European countries". Neuroepidemiology. 7 (3): 122–9. doi:10.1159/000110145. PMID 3405364.
  26. Lauer, K (1989). "Multiple sclerosis in relation to meat preservation in France and Switzerland". Neuroepidemiology. 8 (6): 308–15. doi:10.1159/000110199. PMID 2586701.
  27. Lauer, Klaus (1993-12-01). "A factor-analytical study of the multiple sclerosis mortality in Hesse and Baden-Wuerttemberg, Germany". Journal of Public Health. 1 (4): 319–327. doi:10.1007/BF02959681.
  28. Lauer, K (1990). "Mortality of multiple sclerosis in relation to geographic factors in France". Neuroepidemiology. 9 (3): 113–7. doi:10.1159/000110759. PMID 2402320.
  29. Lauer, K (1989). "Risk of multiple sclerosis in relation to industrial activities: An ecological study in four European countries". Neuroepidemiology. 8 (1): 38–42. doi:10.1159/000110163. PMID 2911392.
  30. Gusev, E; Boiko, A; Lauer, K; Riise, T; Deomina, T (1996). "Environmental risk factors in MS: A case-control study in Moscow". Acta Neurologica Scandinavica. 94 (6): 386–94. doi:10.1111/j.1600-0404.1996.tb00050.x. PMID 9017026.
  31. Lauer, K (1994). "The risk of multiple sclerosis in the U.S.A. In relation to sociogeographic features: A factor-analytic study". Journal of Clinical Epidemiology. 47 (1): 43–8. doi:10.1016/0895-4356(94)90032-9. PMID 8283194.
  32. "Divergent risk of multiple sclerosis in two anabaptist communities in…". Archived from the original on 2014-08-04.
  33. Lauer, K; Alter, M.; Kahana, E.; Zilber, N.; Miller, A. (2007). "Multiple sclerosis frequency in Israel's diverse populations". Neurology. 68 (4): 311, author reply 311. doi:10.1212/01.wnl.0000255650.40828.98. PMID 17242346.
  34. Lauer K (2014-11-12). "The food pattern in geographical relation to the risk of multiple sclerosis in the Mediterranean and Near East region". J Epidemiol Community Health. 45 (3): 251–2. doi:10.1136/jech.45.3.251. PMC 1060768. PMID 1757770.
  35. Klaus Lauer (1997-08-01). "Diet and multiple sclerosis". Neurology. 49 (2 Suppl 2): S55–S61. doi:10.1212/WNL.49.2_Suppl_2.S55. PMID 9270693.
  36. Lauer, K (1991). "The history of nitrite in human nutrition: A contribution from German cookery books". Journal of Clinical Epidemiology. 44 (3): 261–4. doi:10.1016/0895-4356(91)90037-a. PMID 1999685.
  37. "Dr. Klaus Joachim Lauer Biography – Webcast powered by - MULTIWEBCAST - State-of-the-art Webcast Services". Multiwebcast.com. Retrieved 2015-04-01.
  38. Klaus Lauer (2011-06-13). "Multiple sclerosis incidence in the Faroe Islands". Multiple Sclerosis Journal. 17 (11): 1393–1394. doi:10.1177/1352458511408479. PMID 21669934.
  39. Lauer, Klaus (2014). "IJMS | Free Full-Text | Notes on the Epidemiology of Multiple Sclerosis, with Special Reference to Dietary Habits". International Journal of Molecular Sciences. 15 (3): 3533–3545. doi:10.3390/ijms15033533. PMC 3975352. PMID 24577315.
  40. Pugliatti, M.; Casetta, I.; Drulovic, J.; Granieri, E.; Holmøy, T.; Kampman, M. T.; Landtblom, A.-M.; Lauer, K.; Myhr, K.-M.; Parpinel, M.; Pekmezovic, T.; Riise, T.; Zhu, B.; Wolfson, C. (2012-12-20). "A questionnaire for multinational case-control studies of environmental risk factors in multiple sclerosis (EnvIMS-Q)". Acta Neurologica Scandinavica. 126 (195): 43–50. doi:10.1111/ane.12032. PMID 23278656.
  41. Bjørnevik, Kjetil; Riise, Trond; Casetta, Ilaria; Drulovic, Jelena; Granieri, Enrico; Holmøy, Trygve; Kampman, Margitta T.; Landtblom, Anne-Marie; Lauer, Klaus; Lossius, Andreas; Magalhaes, Sandra; Myhr, Kjell-Morten; Pekmezovic, Tatjana; Wesnes, Kristin; Wolfson, Christina; Pugliatti, Maura (2014-01-10). "Sun exposure and multiple sclerosis risk in Norway and Italy: The EnvIMS study". Multiple Sclerosis Journal. 20 (8): 1042–1049. doi:10.1177/1352458513513968. PMID 24414538.
  42. "Abstractverwaltung Congrex". Registration.akm.ch. 2013-10-03. Archived from the original on 2014-07-29. Retrieved 2015-04-01.
  43. Sobocki, P; Pugliatti, M; Lauer, K; Kobelt, G (2007). "Estimation of the cost of MS in Europe: Extrapolations from a multinational cost study". Multiple Sclerosis. 13 (8): 1054–64. doi:10.1177/1352458507077941. PMID 17623729.
  44. Wolfson, C; Granieri, E; Lauer, K (1997). "Case-control studies in multiple sclerosis". Neurology. 49 (2 Suppl 2): S5–14. doi:10.1212/WNL.49.2_Suppl_2.S5. PMID 9270687.
  45. Riise, T; Grønning, M; Fernández, O; Lauer, K; Midgard, R; Minderhoud, J. M.; Nyland, H; Pálffy, G; Poser, S; Aarli, J. A. (1992). "Early prognostic factors for disability in multiple sclerosis, a European multicenter study". Acta Neurologica Scandinavica. 85 (3): 212–8. doi:10.1111/j.1600-0404.1992.tb04031.x. PMID 1575007.
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