Karyopherin alpha 1

Importin subunit alpha-1 is a protein that in humans is encoded by the KPNA1 gene.[5]

KPNA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JDQ, 3TJ3, 4B18
Identifiers
Aliases	KPNA1, IPOA5, NPI-1, RCH2, SRP1, Importin, Karyopherin alpha 1, karyopherin subunit alpha 1
External IDs	OMIM: 600686 MGI: 103560 HomoloGene: 55642 GeneCards: KPNA1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q21.1 Start 122,421,902 bp[1] End 122,514,945 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B3 Start 35,978,750 bp[2] End 36,037,131 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • nuclear localization sequence binding • nuclear import signal receptor activity Cellular component • nuclear pore • nucleoplasm • dendrite • cell nucleus • cytoplasm • cytosol • host cell • GO:0097483, GO:0097481 postsynaptic density • glutamatergic synapse Biological process • regulation of DNA recombination • GO:0046795 intracellular transport of virus • apoptotic DNA fragmentation • protein import into nucleus • protein transport • modulation by virus of host process • NLS-bearing protein import into nucleus • GO:0022415 viral process • postsynapse to nucleus signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3836	16646
Ensembl	ENSG00000114030	ENSMUSG00000022905
UniProt	P52294	Q60960
RefSeq (mRNA)	NM_002264	NM_008465
RefSeq (protein)	NP_002255	NP_032491
Location (UCSC)	Chr 3: 122.42 – 122.51 Mb	Chr 16: 35.98 – 36.04 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Karyopherin alpha 1 has been shown to interact with KPNB1[6][7] and UBR5.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000114030 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022905 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cortes P, Ye ZS, Baltimore D (Sep 1994). "RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1". Proc Natl Acad Sci U S A. 91 (16): 7633–7. Bibcode:1994PNAS...91.7633C. doi:10.1073/pnas.91.16.7633. PMC 44456. PMID 8052633.
6. Köhler, M; Speck C; Christiansen M; Bischoff F R; Prehn S; Haller H; Görlich D; Hartmann E (Nov 1999). "Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import". Mol. Cell. Biol. UNITED STATES. 19 (11): 7782–91. doi:10.1128/mcb.19.11.7782. ISSN 0270-7306. PMC 84838. PMID 10523667.
7. Percipalle, P; Clarkson W D; Kent H M; Rhodes D; Stewart M (Mar 1997). "Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import". J. Mol. Biol. ENGLAND. 266 (4): 722–32. doi:10.1006/jmbi.1996.0801. ISSN 0022-2836. PMID 9102465.
8. Henderson, Michelle J; Russell Amanda J; Hird Samantha; Muñoz Marcia; Clancy Jennifer L; Lehrbach Gillian M; Calanni Sophina T; Jans David A; Sutherland Robert L; Watts Colin K W (Jul 2002). "EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response". J. Biol. Chem. United States. 277 (29): 26468–78. doi:10.1074/jbc.M203527200. ISSN 0021-9258. PMID 12011095.

Further reading

• Bukrinsky MI, Haffar OK (2004). "HIV-1 nuclear import: in search of a leader". Front. Biosci. 2 (4): d578–87. doi:10.2741/A213. PMID 9366553.
• Bukrinsky MI, Haffar OK (1998). "HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr". Mol. Med. 4 (3): 138–43. doi:10.1007/BF03401911. PMC 2230352. PMID 9562972.
• Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.
• Bukrinsky MI, Sharova N, Dempsey MP, et al. (1992). "Active nuclear import of human immunodeficiency virus type 1 preintegration complexes". Proc. Natl. Acad. Sci. U.S.A. 89 (14): 6580–4. Bibcode:1992PNAS...89.6580B. doi:10.1073/pnas.89.14.6580. PMC 49545. PMID 1631159.
• Sharova N, Bukrinskaya A (1991). "p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells". AIDS Res. Hum. Retroviruses. 7 (3): 303–6. doi:10.1089/aid.1991.7.303. PMID 2064827.
• Di Marzio P, Choe S, Ebright M, et al. (1996). "Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr". J. Virol. 69 (12): 7909–16. PMC 189735. PMID 7494303.
• Gallay P, Swingler S, Song J, et al. (1995). "HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase". Cell. 83 (4): 569–76. doi:10.1016/0092-8674(95)90097-7. PMID 7585960.
• Moroianu J, Hijikata M, Blobel G, Radu A (1995). "Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins". Proc. Natl. Acad. Sci. U.S.A. 92 (14): 6532–6. Bibcode:1995PNAS...92.6532M. doi:10.1073/pnas.92.14.6532. PMC 41552. PMID 7604027.
• Freed EO, Englund G, Martin MA (1995). "Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection". J. Virol. 69 (6): 3949–54. doi:10.1128/JVI.69.6.3949-3954.1995. PMC 189124. PMID 7745752.
• Weis K, Mattaj IW, Lamond AI (1995). "Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences". Science. 268 (5213): 1049–53. Bibcode:1995Sci...268.1049W. doi:10.1126/science.7754385. PMID 7754385.
• O'Neill RE, Palese P (1995). "NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein". Virology. 206 (1): 116–25. doi:10.1016/S0042-6822(95)80026-3. PMID 7831767.
• Gallay P, Swingler S, Aiken C, Trono D (1995). "HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator". Cell. 80 (3): 379–88. doi:10.1016/0092-8674(95)90488-3. PMID 7859280.
• Moroianu J, Blobel G, Radu A (1995). "Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2008–11. Bibcode:1995PNAS...92.2008M. doi:10.1073/pnas.92.6.2008. PMC 42412. PMID 7892216.
• von Schwedler U, Kornbluth RS, Trono D (1994). "The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 91 (15): 6992–6. Bibcode:1994PNAS...91.6992V. doi:10.1073/pnas.91.15.6992. PMC 44324. PMID 8041734.
• Heinzinger NK, Bukinsky MI, Haggerty SA, et al. (1994). "The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells". Proc. Natl. Acad. Sci. U.S.A. 91 (15): 7311–5. Bibcode:1994PNAS...91.7311H. doi:10.1073/pnas.91.15.7311. PMC 44389. PMID 8041786.
• Bukrinsky MI, Haggerty S, Dempsey MP, et al. (1993). "A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells". Nature. 365 (6447): 666–9. Bibcode:1993Natur.365..666B. doi:10.1038/365666a0. PMID 8105392.
• Dubrovsky L, Ulrich P, Nuovo GJ, et al. (1996). "Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention". Mol. Med. 1 (2): 217–30. doi:10.1007/BF03401569. PMC 2229944. PMID 8529100.
• Gallay P, Stitt V, Mundy C, et al. (1996). "Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import". J. Virol. 70 (2): 1027–32. doi:10.1128/JVI.70.2.1027-1032.1996. PMC 189908. PMID 8551560.
• Bukrinskaya AG, Ghorpade A, Heinzinger NK, et al. (1996). "Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 367–71. Bibcode:1996PNAS...93..367B. doi:10.1073/pnas.93.1.367. PMC 40239. PMID 8552640.