Kelch-like protein 2

Kelch-like family member 2 is a protein that in humans is encoded by the KLHL2 gene.[5]

KLHL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XN4, 4CHB
Identifiers
Aliases	KLHL2, ABP-KELCH, MAV, MAYVEN, kelch like family member 2
External IDs	OMIM: 605774 MGI: 1924363 HomoloGene: 21416 GeneCards: KLHL2
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q32.3 Start 165,207,561 bp[1] End 165,323,156 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B3.1 Start 64,739,675 bp[2] End 64,850,017 bp[2]
Gene ontology Molecular function • ubiquitin-protein transferase activity • GO:0001948 protein binding • actin binding • identical protein binding Cellular component • ruffle • cell projection • actin cytoskeleton • lamellipodium • cytoskeleton • cytoplasm • Cul3-RING ubiquitin ligase complex • cytosol Biological process • protein ubiquitination • post-translational modification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11275	77113
Ensembl	ENSG00000109466	ENSMUSG00000031605
UniProt	O95198	Q8JZP3
RefSeq (mRNA)	NM_001161521 NM_001161522 NM_007246 NM_001331023 NM_001331024	NM_178633
RefSeq (protein)	NP_001154993 NP_001154994 NP_001317952 NP_001317953 NP_009177	NP_848748
Location (UCSC)	Chr 4: 165.21 – 165.32 Mb	Chr 8: 64.74 – 64.85 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000109466 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031605 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Kelch-like family member 2".

Further reading

• Tseng LA, Bixby JL (Aug 2011). "Interaction of an intracellular pentraxin with a BTB-Kelch protein is associated with ubiquitylation, aggregation and neuronal apoptosis". Molecular and Cellular Neurosciences. 47 (4): 254–64. doi:10.1016/j.mcn.2011.04.005. PMC 3137755. PMID 21549840.
• Korutla L, Wang P, Jackson TG, Mackler SA. "NAC1, a POZ/BTB protein that functions as a corepressor". Neurochemistry International. 54 (3–4): 245–52. doi:10.1016/j.neuint.2008.12.008. PMID 19121354.
• Williams SK, Spence HJ, Rodgers RR, Ozanne BW, Fitzgerald U, Barnett SC (Sep 2005). "Role of Mayven, a kelch-related protein in oligodendrocyte process formation". Journal of Neuroscience Research. 81 (5): 622–31. doi:10.1002/jnr.20588. PMID 16035103.
• Dhanoa BS, Cogliati T, Satish AG, Bruford EA, Friedman JS. "Update on the Kelch-like (KLHL) gene family". Human Genomics. 7: 13. doi:10.1186/1479-7364-7-13. PMC 3658946. PMID 23676014.
• Mai A, Jung SK, Yonehara S (Oct 2004). "hDKIR, a human homologue of the Drosophila kelch protein, involved in a ring-like structure". Experimental Cell Research. 300 (1): 72–83. doi:10.1016/j.yexcr.2004.06.023. PMID 15383316.
• Schumacher FR, Sorrell FJ, Alessi DR, Bullock AN, Kurz T (Jun 2014). "Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation". The Biochemical Journal. 460 (2): 237–46. doi:10.1042/BJ20140153. PMC 4019986. PMID 24641320.
• Soltysik-Espanola M, Rogers RA, Jiang S, Kim TA, Gaedigk R, White RA, Avraham H, Avraham S (Jul 1999). "Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain". Molecular Biology of the Cell. 10 (7): 2361–75. doi:10.1091/mbc.10.7.2361. PMC 25454. PMID 10397770.
• Bu X, Avraham HK, Li X, Lim B, Jiang S, Fu Y, Pestell RG, Avraham S (Mar 2005). "Mayven induces c-Jun expression and cyclin D1 activation in breast cancer cells". Oncogene. 24 (14): 2398–409. doi:10.1038/sj.onc.1208466. PMID 15735724.
• Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S (Aug 2013). "KLHL2 interacts with and ubiquitinates WNK kinases". Biochemical and Biophysical Research Communications. 437 (3): 457–62. doi:10.1016/j.bbrc.2013.06.104. PMID 23838290.