Kelch-like protein 12

Kelch-like protein 12 is a protein that in humans is encoded by the KLHL12 gene.[5][6]

KLHL12
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKLHL12, C3IP1, DKIR, hDKIR, kelch like family member 12
External IDsOMIM: 614522 MGI: 2385619 HomoloGene: 23317 GeneCards: KLHL12
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q32.1Start202,891,116 bp[1]
End202,928,636 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

59349

240756

Ensembl

ENSG00000117153

ENSMUSG00000026455

UniProt

Q53G59

Q8BZM0

RefSeq (mRNA)

NM_001303051
NM_001303109
NM_021633

NM_153128
NM_001311136

RefSeq (protein)

NP_001289980
NP_001290038
NP_067646

NP_001298065
NP_694768

Location (UCSC)Chr 1: 202.89 – 202.93 MbChr 1: 134.46 – 134.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

KLHL12 has been shown to interact with RIT1[7] and CUL3.[7]

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gollark: I like making 4x4x4 interface/assembler cubes.
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References
  1. GRCh38: Ensembl release 89: ENSG00000117153 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026455 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  6. "Entrez Gene: KLHL12 kelch-like 12 (Drosophila)".
  7. Rondou P, Haegeman G, Vanhoenacker P, Van Craenenbroeck K (April 2008). "BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase". The Journal of Biological Chemistry. 283 (17): 11083–96. doi:10.1074/jbc.M708473200. PMC 2431063. PMID 18303015.

Further reading
  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Mai A, Jung SK, Yonehara S (October 2004). "hDKIR, a human homologue of the Drosophila kelch protein, involved in a ring-like structure". Experimental Cell Research. 300 (1): 72–83. doi:10.1016/j.yexcr.2004.06.023. PMID 15383316.
  • Uchida K, Akita Y, Matsuo K, Fujiwara S, Nakagawa A, Kazaoka Y, et al. (September 2005). "Identification of specific autoantigens in Sjögren's syndrome by SEREX". Immunology. 116 (1): 53–63. doi:10.1111/j.1365-2567.2005.02197.x. PMC 1802401. PMID 16108817.
  • Angers S, Thorpe CJ, Biechele TL, Goldenberg SJ, Zheng N, MacCoss MJ, Moon RT (April 2006). "The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation". Nature Cell Biology. 8 (4): 348–57. doi:10.1038/ncb1381. PMID 16547521.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
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