Kelch-like protein 1

Kelch-like protein 1 is a protein that in humans is encoded by the KLHL1 gene.[4][5]

KLHL1
Identifiers
Aliases	KLHL1, MRP2, kelch like family member 1
External IDs	OMIM: 605332 MGI: 2136335 HomoloGene: 56903 GeneCards: KLHL1
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q21.33 Start 69,700,594 bp[1] End 70,108,493 bp[1]
Gene ontology Molecular function • ubiquitin-protein transferase activity • actin binding Cellular component • Cul3-RING ubiquitin ligase complex • cytoskeleton • dendrite • neuronal cell body • cytoplasm Biological process • cerebellar Purkinje cell layer development • actin cytoskeleton organization • locomotory behavior • adult walking behavior • dendrite development • protein ubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57626	93688
Ensembl	ENSG00000150361	n/a
UniProt	Q9NR64	Q9JI74
RefSeq (mRNA)	NM_020866 NM_001286725	NM_053105
RefSeq (protein)	NP_001273654 NP_065917	NP_444335
Location (UCSC)	Chr 13: 69.7 – 70.11 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000150361 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Nemes JP, Benzow KA, Moseley ML, Ranum LP, Koob MD (Sep 2000). "The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1)". Hum Mol Genet. 9 (10): 1543–51. doi:10.1093/hmg/9.10.1543. PMID 10888605.
5. "Entrez Gene: KLHL1 kelch-like 1 (Drosophila)".

Further reading

• Aromolaran KA, Benzow KA, Koob MD, Piedras-Rentería ES (2007). "The Kelch-like protein 1 modulates P/Q-type calcium current density". Neuroscience. 145 (3): 841–50. doi:10.1016/j.neuroscience.2006.12.046. PMID 17289272.
• Seng S, Avraham HK, Jiang S, et al. (2007). "KLHL1/MRP2 mediates neurite outgrowth in a glycogen synthase kinase 3beta-dependent manner". Mol. Cell. Biol. 26 (22): 8371–84. doi:10.1128/MCB.02167-05. PMC 1636797. PMID 16982692.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.