KIRREL2

Kin of IRRE-like protein 2, also known as NEPH3, is a protein that in humans is encoded by the KIRREL2 gene.[5][6][7] It is primarily expressed in β cells of the pancreatic islets.[5]

KIRREL2
Identifiers
Aliases	KIRREL2, FILTRIN, NEPH3, NLG1, kin of IRRE like 2 (Drosophila), kirre like nephrin family adhesion molecule 2
External IDs	OMIM: 607762 MGI: 2442334 HomoloGene: 35249 GeneCards: KIRREL2
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.12 Start 35,855,861 bp[1] End 35,867,109 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B1 Start 30,447,534 bp[2] End 30,457,690 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • identical protein binding Cellular component • integral component of membrane • slit diaphragm • membrane • cell membrane • intercellular junction Biological process • negative regulation of protein phosphorylation • cell adhesion • cell-cell adhesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84063	243911
Ensembl	ENSG00000126259	ENSMUSG00000036915
UniProt	Q6UWL6	Q7TSU7
RefSeq (mRNA)	NM_032123 NM_199179 NM_199180 NM_001329530 NM_001363667	NM_172898
RefSeq (protein)	NP_001316459 NP_115499 NP_954648 NP_954649 NP_001350596	NP_766486
Location (UCSC)	Chr 19: 35.86 – 35.87 Mb	Chr 7: 30.45 – 30.46 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

KIRREL2 is a member of the NEPH protein family, which includes NEPH1 (KIRREL) and NEPH2 (KIRREL3). NEPH proteins bind the

References

1. GRCh38: Ensembl release 89: ENSG00000126259 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036915 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sun C, Kilburn D, Lukashin A, Crowell T, Gardner H, Brundiers R, Diefenbach B, Carulli JP (Jul 2003). "Kirrel2, a novel immunoglobulin superfamily gene expressed primarily in beta cells of the pancreatic islets". Genomics. 82 (2): 130–42. doi:10.1016/S0888-7543(03)00110-1. PMID 12837264.
6. Ihalmo P, Palmen T, Ahola H, Valtonen E, Holthofer H (Dec 2002). "Filtrin is a novel member of nephrin-like proteins". Biochem Biophys Res Commun. 300 (2): 364–70. doi:10.1016/S0006-291X(02)02854-1. PMID 12504092.
7. "Entrez Gene: KIRREL2 kin of IRRE like 2 (Drosophila)".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rinta-Valkama J, Aaltonen P, Lassila M, et al. (2007). "Densin and filtrin in the pancreas and in the kidney, targets for humoral autoimmunity in patients with type 1 diabetes". Diabetes Metab. Res. Rev. 23 (2): 119–26. doi:10.1002/dmrr.655. PMID 16741999.