KDM8

KDM8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3UYJ, 4AAP, 4GAZ, 4GJY, 4GJZ, 4QU1
Identifiers
Aliases	KDM8, JMJD5, lysine demethylase 8
External IDs	OMIM: 611917 MGI: 1924285 HomoloGene: 49791 GeneCards: KDM8
Gene location (Human)
Chr.	Chromosome 16 (human)[1]
End	27,221,768 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	125,462,269 bp[2]
Gene ontology
Molecular function	• dioxygenase activity; • chromatin binding; • oxidoreductase activity; • metal ion binding; • histone demethylase activity (H3-K36 specific); • histone demethylase activity; • GO:0001948 protein binding; • peptidase activity; • hydrolase activity; • aminopeptidase activity; • endopeptidase activity; • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; • methylated histone binding;
Cellular component	• cell nucleus; • nucleoplasm; • cytosol; • chromosome;
Biological process	• regulation of transcription, DNA-templated; • cell cycle; • G2/M transition of mitotic cell cycle; • oxidation-reduction process; • positive regulation of transcription, DNA-templated; • histone H3-K36 demethylation; • transcription, DNA-templated; • proteolysis; • chromatin organization; • protein destabilization; • circadian regulation of gene expression; • negative regulation of transcription, DNA-templated; • rhythmic process;
	Sources:Amigo / QuickGO
Orthologs
	79831
	77035
	ENSG00000155666
	ENSMUSG00000030752
	Q8N371
	Q9CXT6
	NM_001145348; NM_024773
	NM_029842
	NP_001138820; NP_079049
	NP_084118
	Wikidata
View/Edit Human	View/Edit Mouse

Lysine demethylase 8 is a protein that in humans is encoded by the KDM8 gene.[5]

Function

This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.

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gollark: There aren't actually any mathematical proofs that breaking RSA and AES and whatever actually requires a really large amount of operations.

gollark: C does not have compile-time detection of such mistakes, so that's tricky.

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gollark: It might not not not not be.

References

GRCh38: Ensembl release 89: ENSG00000155666 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030752 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Lysine demethylase 8". Retrieved 2016-04-09.

KDM8

Function

References

Further reading