KDM6B

Lysine demethylase 6B is a protein that in humans is encoded by the KDM6B gene. [5]

KDM6B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKDM6B, JMJD3, lysine demethylase 6B, NEDCFSA
External IDsOMIM: 611577 MGI: 2448492 HomoloGene: 18945 GeneCards: KDM6B
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17p13.1Start7,839,904 bp[1]
End7,854,796 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

23135

216850

Ensembl

ENSG00000132510

ENSMUSG00000018476

UniProt

O15054

Q5NCY0

RefSeq (mRNA)

NM_001080424
NM_001348716

NM_001017426

RefSeq (protein)

NP_001073893
NP_001335645

NP_001017426

Location (UCSC)Chr 17: 7.84 – 7.85 MbChr 11: 69.4 – 69.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Regulation during differentation

KDM6B was found to be expressional increased during cardiac and endothelial differentation of murine embryonic stem cells.[6]

Small molecule inhibition

A small molecule inhibition (GSK-J1) has been developed to inhibit jumonji domain of KDM6 histone demethylase family to modulate proinflammatory response in macrophage.[7]

gollark: `4 in [4]` is a bit of a wart in my opinion (when will you need it?) but kind of makes sense.
gollark: It's not as if things have to exactly match natural language.
gollark: <@330678593904443393> hahahanope.
gollark: Or `arr.indexOf(x) > -1`.
gollark: Use `arr.includes(x)` instead.

References

  1. GRCh38: Ensembl release 89: ENSG00000132510 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000018476 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Lysine demethylase 6B". Retrieved 2016-04-09.
  6. Boeckel, Jes-Niels; Derlet, Anja; Glaser, Simone F.; Luczak, Annika; Lucas, Tina; Heumüller, Andreas W.; Krüger, Marcus; Zehendner, Christoph M.; Kaluza, David (July 2016). "JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells". Arteriosclerosis, Thrombosis, and Vascular Biology. 36 (7): 1425–1433. doi:10.1161/ATVBAHA.116.307695. ISSN 1524-4636. PMID 27199445.
  7. Kruidenier, Laurens; Chung, Chun-wa; Cheng, Zhongjun; Liddle, John; Che, KaHing; Joberty, Gerard; Bantscheff, Marcus; Bountra, Chas; Bridges, Angela (2012-08-16). "A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response". Nature. 488 (7411): 404–408. Bibcode:2012Natur.488..404K. doi:10.1038/nature11262. ISSN 1476-4687. PMC 4691848. PMID 22842901.

Further reading

  • Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, Issaeva I, Canaani E, Salcini AE, Helin K (2007). "UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development". Nature. 449 (7163): 731–4. Bibcode:2007Natur.449..731A. doi:10.1038/nature06145. PMID 17713478.


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