KDM6B

KDM6B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XUE, 2XXZ, 4ASK, 5FP3
Identifiers
Aliases	KDM6B, JMJD3, lysine demethylase 6B, NEDCFSA
External IDs	OMIM: 611577 MGI: 2448492 HomoloGene: 18945 GeneCards: KDM6B
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	7,854,796 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	69,413,675 bp[2]
Gene ontology
Molecular function	• sequence-specific DNA binding; • beta-catenin binding; • chromatin binding; • dioxygenase activity; • metal ion binding; • GO:0001948 protein binding; • oxidoreductase activity; • histone demethylase activity; • histone demethylase activity (H3-K27 specific); • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • chromatin DNA binding;
Cellular component	• nucleoplasm; • cell nucleus; • MLL3/4 complex;
Biological process	• response to fungicide; • histone demethylation; • cell fate commitment; • inflammatory response to antigenic stimulus; • cardiac muscle cell differentiation; • response to activity; • mesodermal cell differentiation; • regulation of gene expression; • endothelial cell differentiation; • inflammatory response; • hippocampus development; • oxidation-reduction process; • positive regulation of transcription from RNA polymerase II promoter; • cellular response to hydrogen peroxide; • histone H3-K27 demethylation; • chromatin remodeling; • chromatin organization; • positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	23135
	216850
	ENSG00000132510
	ENSMUSG00000018476
	O15054
	Q5NCY0
	NM_001080424; NM_001348716
	NM_001017426
	NP_001073893; NP_001335645
	NP_001017426
	Wikidata
View/Edit Human	View/Edit Mouse

Lysine demethylase 6B is a protein that in humans is encoded by the KDM6B gene. [5]

Regulation during differentation

KDM6B was found to be expressional increased during cardiac and endothelial differentation of murine embryonic stem cells.[6]

Small molecule inhibition

A small molecule inhibition (GSK-J1) has been developed to inhibit jumonji domain of KDM6 histone demethylase family to modulate proinflammatory response in macrophage.[7]

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References

GRCh38: Ensembl release 89: ENSG00000132510 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000018476 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Lysine demethylase 6B". Retrieved 2016-04-09.
Boeckel, Jes-Niels; Derlet, Anja; Glaser, Simone F.; Luczak, Annika; Lucas, Tina; Heumüller, Andreas W.; Krüger, Marcus; Zehendner, Christoph M.; Kaluza, David (July 2016). "JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells". Arteriosclerosis, Thrombosis, and Vascular Biology. 36 (7): 1425–1433. doi:10.1161/ATVBAHA.116.307695. ISSN 1524-4636. PMID 27199445.
Kruidenier, Laurens; Chung, Chun-wa; Cheng, Zhongjun; Liddle, John; Che, KaHing; Joberty, Gerard; Bantscheff, Marcus; Bountra, Chas; Bridges, Angela (2012-08-16). "A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response". Nature. 488 (7411): 404–408. Bibcode:2012Natur.488..404K. doi:10.1038/nature11262. ISSN 1476-4687. PMC 4691848. PMID 22842901.

KDM6B

Regulation during differentation

Small molecule inhibition

References

Further reading