KDM3A

KDM3A
Identifiers
Aliases	KDM3A, JHDM2A, JHMD2A, JMJD1, JMJD1A, TSGA, lysine demethylase 3A
External IDs	OMIM: 611512 MGI: 98847 HomoloGene: 10196 GeneCards: KDM3A
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	86,492,716 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	71,632,990 bp[2]
Gene ontology
Molecular function	• iron ion binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • dioxygenase activity; • metal ion binding; • androgen receptor binding; • oxidoreductase activity; • histone demethylase activity; • transcription regulatory region sequence-specific DNA binding; • chromatin DNA binding; • histone demethylase activity (H3-K9 specific); • GO:0001948 protein binding; • RNA polymerase II core promoter sequence-specific DNA binding;
Cellular component	• cytoplasm; • membrane; • nucleoplasm; • cell nucleus; • chromatin;
Biological process	• androgen receptor signaling pathway; • cell differentiation; • regulation of transcription, DNA-templated; • histone H3-K9 dimethylation; • regulation of stem cell differentiation; • regulation of stem cell population maintenance; • transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • spermatogenesis; • hormone-mediated signaling pathway; • negative regulation of histone H3-K9 methylation; • regulation of gene expression; • formaldehyde biosynthetic process; • spermatid nucleus elongation; • oxidation-reduction process; • positive regulation of transcription from RNA polymerase II promoter; • covalent chromatin modification; • histone H3-K9 demethylation; • cellular response to leukemia inhibitory factor; • chromatin organization; • positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	55818
	104263
	ENSG00000115548
	ENSMUSG00000053470
	Q9Y4C1
	Q6PCM1
	NM_001146688; NM_018433
	NM_001038695; NM_173001; NM_001362200; NM_001362201
	NP_001140160; NP_060903
	NP_001033784; NP_766589; NP_001349129; NP_001349130
	Wikidata
View/Edit Human	View/Edit Mouse

Lysine demethylase 3A is a protein that in humans is encoded by the KDM3A gene.[5]

Function

This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants.

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References

GRCh38: Ensembl release 89: ENSG00000115548 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000053470 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Lysine demethylase 3A".

KDM3A

Function

References

Further reading