KCTD13

BTB/POZ domain-containing protein KCTD13 is a protein that in humans is encoded by the KCTD13 gene.[5][6]

KCTD13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UIJ
Identifiers
Aliases	KCTD13, BACURD1, PDIP1, POLDIP1, hBACURD1, FKSG86, potassium channel tetramerization domain containing 13
External IDs	OMIM: 608947 MGI: 1923739 HomoloGene: 27800 GeneCards: KCTD13
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 29,905,012 bp[1] End 29,926,236 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 126,928,879 bp[2] End 126,945,631 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ubiquitin-protein transferase activity • GTP-Rho binding • GO:0001948 protein binding • identical protein binding • protein domain specific binding Cellular component • Cul3-RING ubiquitin ligase complex • cell nucleus • nuclear body Biological process • positive regulation of DNA replication • DNA replication • protein homooligomerization • cell migration • protein ubiquitination • stress fiber assembly • proteasome-mediated ubiquitin-dependent protein catabolic process • negative regulation of Rho protein signal transduction • positive regulation of synaptic transmission • neural precursor cell proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	253980	233877
Ensembl	ENSG00000174943	ENSMUSG00000030685
UniProt	Q8WZ19	Q8BGV7
RefSeq (mRNA)	NM_178863	NM_172747
RefSeq (protein)	NP_849194	NP_766335
Location (UCSC)	Chr 16: 29.91 – 29.93 Mb	Chr 7: 126.93 – 126.95 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

KCTD13 has been shown to interact with PCNA.[5]

Clinical relevance

Mutations in this gene have been associated to abnormalities in brain growth and behaviour.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000174943 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030685 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. He H, Tan CK, Downey KM, So AG (October 2001). "A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen". Proceedings of the National Academy of Sciences of the United States of America. 98 (21): 11979–84. Bibcode:2001PNAS...9811979H. doi:10.1073/pnas.221452098. PMC 59753. PMID 11593007.
6. "Entrez Gene: KCTD13 potassium channel tetramerisation domain containing 13".
7. Arbogast T, Razaz P, Ellegood J, McKinstry SU, Erdin S, Currall B, et al. (May 2019). "Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions". Human Molecular Genetics. 28 (9): 1474–1486. doi:10.1093/hmg/ddy436. PMC 6489413. PMID 30590535.

Further reading

• Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, et al. (July 2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Research. 30 (14): 3163–70. doi:10.1093/nar/gkf428. PMC 135748. PMID 12136098.
• Zhou J, Hu X, Xiong X, Liu X, Liu Y, Ren K, et al. (March 2005). "Cloning of two rat PDIP1 related genes and their interactions with proliferating cell nuclear antigen". Journal of Experimental Zoology. Part A, Comparative Experimental Biology. 303 (3): 227–40. doi:10.1002/jez.a.150. PMID 15726626.
• Tomaru T, Satoh T, Yoshino S, Ishizuka T, Hashimoto K, Monden T, et al. (January 2006). "Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma". Endocrinology. 147 (1): 377–88. doi:10.1210/en.2005-0450. PMID 16239304.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human KCTD13