KCNRG

Potassium channel regulator, also known as KCNRG, is a protein which in humans is encoded by theKCNRG gene.[5][6]

KCNRG
Identifiers
Aliases	KCNRG, DLTET, potassium channel regulator
External IDs	OMIM: 607947 MGI: 2685591 HomoloGene: 35259 GeneCards: KCNRG
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.2 Start 50,015,254 bp[1] End 50,020,922 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D1 Start 61,607,457 bp[2] End 61,612,826 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • identical protein binding Cellular component • endoplasmic reticulum Biological process • protein homooligomerization • negative regulation of delayed rectifier potassium channel activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	283518	328424
Ensembl	ENSG00000198553	ENSMUSG00000046168
UniProt	Q8N5I3	Q2TUM3
RefSeq (mRNA)	NM_199464 NM_173605	NM_001039105 NM_206974
RefSeq (protein)	NP_775876 NP_955751	NP_001034194 NP_996857
Location (UCSC)	Chr 13: 50.02 – 50.02 Mb	Chr 14: 61.61 – 61.61 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

KCNRG is a soluble protein with characteristics suggesting it forms hetero-tetramers with voltage-gated K⁺ channels and inhibits their function.[5]

Clinical significance

KCNRG has been found to be predominantly expressed in lung tissue. Additionally, KCNRG transcripts are also found in liver and some other tissues, but in lower extent. Researchers at Uppsala University have found that KCNRG is found in the lower lung and constitutes an autoantigen in a rare disorder named autoimmune polyendocrine syndrome type 1 (APS1). As a subset of patients with APS1 suffer from respiratory disease, an autoimmune reaction against KCNRG may explain the respiratory disease in these patients. KCNRG may also be connected to common nonfatal diseases like asthma and chronic bronchitis.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000198553 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046168 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: KCNRG potassium channel regulator".
6. Ivanov DV, Tyazhelova TV, Lemonnier L, Kononenko N, Pestova AA, Nikitin EA, Prevarskaya N, Skryma R, Panchin YV, Yankovsky NK, Baranova AV (March 2003). "A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3". FEBS Lett. 539 (1–3): 156–60. doi:10.1016/S0014-5793(03)00211-4. PMID 12650944.
7. Alimohammadi M, Dubois N, Sköldberg F, Hallgren A, Tardivel I, Hedstrand H, Haavik J, Husebye ES, Gustafsson J, Rorsman F, Meloni A, Janson C, Vialettes B, Kajosaari M, Egner W, Sargur R, Pontén F, Amoura Z, Grimfeld A, De Luca F, Betterle C, Perheentupa J, Kämpe O, Carel JC (February 2009). "Pulmonary autoimmunity as a feature of autoimmune polyendocrine syndrome type 1 and identification of KCNRG as a bronchial autoantigen". Proc. Natl. Acad. Sci. U.S.A. 106 (11): 4396–401. doi:10.1073/pnas.0809986106. PMC 2648890. PMID 19251657.

Further reading

• Cho YG, Kim CJ, Song JH, et al. (2006). "Genetic and expression analysis of the KCNRG gene in hepatocellular carcinomas". Exp. Mol. Med. 38 (3): 247–55. doi:10.1038/emm.2006.30. PMID 16819283.
• Skoblov M, Shakhbazov K, Oshchepkov D, et al. (2006). "Human RFP2 gene promoter: Unique structure and unusual strength". Biochem. Biophys. Res. Commun. 342 (3): 859–66. doi:10.1016/j.bbrc.2006.01.187. PMC 1994241. PMID 16499869.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Corcoran MM, Hammarsund M, Zhu C, et al. (2004). "DLEU2 encodes an antisense RNA for the putative bicistronic RFP2/LEU5 gene in humans and mouse". Genes Chromosomes Cancer. 40 (4): 285–97. doi:10.1002/gcc.20046. PMID 15188451.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ivanov DV, Tyazhelova TV, Lemonnier L, et al. (2003). "A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3". FEBS Lett. 539 (1–3): 156–60. doi:10.1016/S0014-5793(03)00211-4. PMID 12650944.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.