KATNA1

Katanin p60 ATPase-containing subunit A1 is an enzyme that in humans is encoded by the KATNA1 gene.[5][6]

KATNA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RPA
Identifiers
Aliases	KATNA1, katanin catalytic subunit A1
External IDs	OMIM: 606696 MGI: 1344353 HomoloGene: 56014 GeneCards: KATNA1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.1 Start 149,594,873 bp[1] End 149,648,972 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A1 Start 7,726,000 bp[2] End 7,763,150 bp[2]
Gene ontology Molecular function • nucleotide binding • microtubule binding • microtubule-severing ATPase activity • GO:0001948 protein binding • protein heterodimerization activity • hydrolase activity • ATP binding • ATPase activity • isomerase activity Cellular component • cytoplasm • spindle pole • midbody • microtubule • cytoskeleton • cell nucleus • microtubule organizing center • spindle • mitotic spindle pole • centrosome Biological process • cell division • microtubule severing • cell cycle • cytoplasmic microtubule organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11104	23924
Ensembl	ENSG00000186625	ENSMUSG00000019794
UniProt	O75449	Q9WV86
RefSeq (mRNA)	NM_001204076 NM_007044	NM_011835
RefSeq (protein)	NP_001191005 NP_008975	n/a
Location (UCSC)	Chr 6: 149.59 – 149.65 Mb	Chr 10: 7.73 – 7.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000186625 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019794 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. McNally FJ, Thomas S (Jan 1999). "Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs". Mol Biol Cell. 9 (7): 1847–61. doi:10.1091/mbc.9.7.1847. PMC 25426. PMID 9658175.
6. "Entrez Gene: KATNA1 katanin p60 (ATPase-containing) subunit A 1".

Further reading

• McNally FJ, Vale RD (1993). "Identification of katanin, an ATPase that severs and disassembles stable microtubules". Cell. 75 (3): 419–29. doi:10.1016/0092-8674(93)90377-3. PMID 8221885.
• McNally FJ, Okawa K, Iwamatsu A, Vale RD (1997). "Katanin, the microtubule-severing ATPase, is concentrated at centrosomes". J. Cell Sci. 109 (3): 561–7. PMID 8907702.
• Hartman JJ, Mahr J, McNally K, et al. (1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit". Cell. 93 (2): 277–87. doi:10.1016/S0092-8674(00)81578-0. PMID 9568719.
• Ahmad FJ, Yu W, McNally FJ, Baas PW (1999). "An essential role for katanin in severing microtubules in the neuron". J. Cell Biol. 145 (2): 305–15. doi:10.1083/jcb.145.2.305. PMC 2133110. PMID 10209026.
• Syu LJ, Saltiel AR (1999). "Lipotransin: a novel docking protein for hormone-sensitive lipase". Mol. Cell. 4 (1): 109–15. doi:10.1016/S1097-2765(00)80192-6. PMID 10445032.
• McNally KP, Bazirgan OA, McNally FJ (2000). "Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin". J. Cell Sci. 113 (9): 1623–33. PMID 10751153.
• Buster D, McNally K, McNally FJ (2002). "Katanin inhibition prevents the redistribution of gamma-tubulin at mitosis". J. Cell Sci. 115 (Pt 5): 1083–92. PMID 11870226.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.