John Buster

John Edmond Buster (born July 18, 1941) is an American physician who, while working at the University of California at Los Angeles School of Medicine, directed the research team that performed the first embryo transfer from one woman to another resulting in a live birth. It was performed at the Harbor-UCLA Medical Center,[1] reported in July 1983, and culminated in the announcement of the birth on February 3, 1984.[2] In the procedure, an embryo that was just beginning to develop was transferred from the woman in whom it had been conceived by artificial insemination to another woman who gave birth to the infant 38 weeks later. The sperm used in the artificial insemination came from the husband of the woman who bore the baby.[3][4]

Dr. John E. Buster

Buster and other members of the UCLA research team were featured in People Magazine,[5] and Time Magazine.[4] Building upon Buster's research, over 200,000 live births resulting from donor embryo transfer have been recorded by the Centers for Disease Control(CDC)[6] in the United States.[7][8][9]

Buster continues to practice medicine as a reproductive endocrinologist at Women and Infants' Fertility Center in Providence, Rhode Island.[10]

Education

Buster attended Stanford University for his undergraduate degree and earned both his medical degree and residency training in obstetrics and gynecology from the University of California Los Angeles School of Medicine, where he later completed fellowship training in reproductive endocrinology and infertility.[11]

Career

Buster works in the Division of Reproductive Endocrinology and Infertility at Women & Infants Hospital[12] in Providence, Rhode Island. He is also engaged in private practice and in clinical teaching of Reproductive Endocrinology and Infertility at the Women & Infants/Alpert Medical School (Brown University)[13] fellowship in reproductive endocrinology and infertility.[14]

Research

Buster's research and clinical practice in reproductive medicine include published studies in steroid physiology, pre-implantation embryology, pregnancy loss, and menopausal hormone replacement therapy.

Buster authored "Sex and the 50-Something Woman: Strategies for Restoring Satisfaction" in the journal Contemporary Obstetrics and Gynecology.[15] The intent was to explain the various causes of female sexual dysfunction (FSD) and the simple interventions obstetrician/gynecologists and primary care physicians can recommend. The article attracted national interest with stories appearing in local media.[16]

One of Buster's earliest research studies focused on steroid hormone radioimmunoassay (RIA).[17] He reported an RIA for the androgen prohormone, dehydroepiandrosterone sulfate (DHEA-S), the direct measurement of which was shown to be possible in un-extracted serum.[18] Refined versions of his methodology are used in the diagnosis and management of androgen excess disorders in women.[19] He also described for the first time the simultaneous progression of multiple androgen, progestin, and estrogen concentrations in maternal blood throughout all three trimesters of pregnancy and into the onset of labor.[20]

Buster helped develop a testosterone delivery system for women researched by Procter & Gamble. It is marketed in Europe under the brand name Intrinsa.[21] Buster served as lead investigator in another study demonstrating the effectiveness of an estradiol mist,[22] which has pharmacology similar to those of a trans-dermal estrogen patches. Sold in the United States by Perrigo under the name Evamist, it received FDA approval in 2007.[23] Buster's Phase III Study for Evamist was published in the journal, Obstetrics & Gynecology.[24]

In the early 1980s, over a period of 4 years, at the University of California at Los Angeles School of Medicine,[1] Buster and his team developed a technique based on in vivo fertilization and uterine lavage – a method adapted from the commercialization of bovine embryo transfer in the cattle industry – as a means to transfer human blastocysts from fertile woman donors to ovulating or agonadal infertile recipient women.[25] In February 1984, the first live birth, followed 3 months later by a second live birth, resulted from these techniques and was reported by Buster and his team.[26]

Buster updated the uterine lavage technology adapting it to diagnosis and prevention of genetic diseases in embryos. In 2011 Buster founded Previvo Genetics, Inc. He serves on the Board of Directors and Scientific Board.[27]

In April 2019 at the International Federation of Fertility Societies (IFFS)World Congress in Shanghai, China, Buster presented the preliminary results from the first Preimplantation Genetic Testing (PGT) using in vivo Embryos recovered by Uterine Lavage.[28]

In January, 2020, Buster with the Previvo research team reported the first large series (134 hyper stimulation/lavage cycles) describing the successful and safe recovery of 136 in vivo fertilized and matured embryos using in vivo uterine lavage (IVL).[29] For controls, 20 of the lavage subjects also underwent in vitro fertilization (IVF). Most significantly the morphology scores of the IVL blastocysts were significantly higher than the IVF controls.

Awards and honors

Buster received the Legends Award in May 2012 from LA BioMed located at Harbor-UCLA Medical Center.[30][31]

In June 2014 the American College of Obstetricians and Gynecologists (ACOG) awarded a permanently endowed lectureship, the John E. Buster, M.D. lectureship on cutting edge reproductive medicine. This lecture is given annually.[32][33]

Publications
  • Buster, JohnE.; Bustillo, Maria; Thorneycroft, IanH.; Simon, JamesA.; Boyers, StephenP.; Marshall, JohnR.; Louw, JohnA.; Seed, RandolphW.; Seed, RichardG. (July 1983). "Non-surgical transfer of in vivo fertilised donated ova to five infertile women: report of two pregnancies". The Lancet. 322 (8343): 223–224. doi:10.1016/S0140-6736(83)90208-8. PMID 6135059.
  • Bustillo, M; Buster, JE; Cohen, SW; Hamilton, F; Thorneycroft, IH; Simon, JA; Rodi, IA; Boyers, SP; Marshall, JR; Louw, JA (17 February 1984). "Delivery of a healthy infant following nonsurgical ovum transfer". JAMA. 251 (7): 889. doi:10.1001/jama.1984.03340310011002. PMID 6694286.
  • Buster, JohnE.; Bustillo, Maria; Thorneycroft, Ian; Simon, JamesA.; Boyers, StephenP.; Marshall, JohnR.; Seed, RichardG.; Louw, JohnA. (April 1983). "Non-surgical transfer of an in-vivo fertilised donated ovum to an infertility patient". The Lancet. 321 (8328): 816–817. doi:10.1016/S0140-6736(83)91868-8. PMID 6132146.
  • Buster, John E. (2008). "The first live birth donation". Society for Reproductive Medicine. 4 (4): 23–8.
  • Center for Disease Control and Prevention/Society for Assisted Reproductive Technology Fertility Clinic Reports, 1994–2006.
  • Buster, John E.; Bustillo, Maria; Rodi, Ingrid A.; Cohen, Sydlee W.; Hamilton, Minda; Simon, James A.; Thorneycroft, Ian H.; Marshall, John R. (September 1985). "Biologic and morphologic development of donated human ova recovered by nonsurgical uterine lavage". American Journal of Obstetrics and Gynecology. 153 (2): 211–217. doi:10.1016/0002-9378(85)90116-4. PMID 4037016.
  • Buster JE, Abraham GE: Radioimmunoassay of plasma dehydroepiandrosterone sulfate. Analyt Lett 5:543:551, 1972.
  • Buster JE, Freeman AG, Hobel CJ: An algorithm for determining gestational age from unconjugated estriol levels. Obstet Gynecol. Nov; 56 (5): 649-655, 1980.
  • Buster JE, Chang RJ, Preston DL, Elashoff RM, Cousins LM, Abraham GE, Hobel CJ, Marshall JR: Interrelationships of circulating maternal steroid concentrations in third trimester pregnancies: II. C18 and C19 steroids: estradiol, estriol, dihydro-epiandrosterone, dehydroepiandrosterone sulfate, ∆5androstenedione, testosterone, and dihydrotestosterone. J Clin Endocrinol Metab 48 (1): 139-142, 1979.
  • Buster JE, Change RJ, Preston, DL, Elashoff RM, Cousins LM, Abraham GE, Hobel, CJ, Marshall JR: Interrelationships of circulating maternal steroid concentrations in third trimester pregnancies. I. C21 steroids: progesterone, 16ά-hydroxyprogesterone, 17ά -hydroxy-progesterone, 20ά-dihydroprogesterone, ∆5-pregnenolone, ∆5-pregnenonlone sulfate and 17-hydroxy ∆5-pregnenolone. J Clin Endocrinol Metab 48 (1) 33-38, 1979
  • Rodi IA, Sauer MV, Gorrill MJ, Bustillo M, Gunning JE, Buster JE, Marshall JR: The medical treatment of unruptured ectopic pregnancy with methotrexate and citrovorum rescue: preliminary experience. Fertil Steril. Nov;46 (5): 811-813, 1986.
  • Carson SA, Buster JE: Ectopic pregnancy. N Engl J Med. Oct; 329 (16): 1174–1181, 1993.
  • Buster JE, Kingsberg SA, Aguirre O, Brown C, Breaux JG, Buch A, Rodenberg CA, Wekselman K, Casson P: Testosterone Patch for Low Sexual Desire in Surgically Menopausal Women: A Randomized Trial. Obstet Gynecol, 2005 May; 105(5 Pt 1):944-52.
  • Buster JE, Koltun WD, Pascual MLG, Day WW, Peterson C: Low-dose estradiol spray to treat vasomotor symptoms. Obstet Gynecol 111: 1343–1351, 2008.
  • Buster, JE. Principles of Oocyte and Embryo Donation (Sauer M, ed). “Historical "Evolution of Oocyte and Embryo Donation as a Treatment for Intractable Infertility” Chapter 1, pp 1–10. ISBN 0387949607.
gollark: So I was looking at alternatives, and I remembered that I had a prototype search thing sitting on my disk somewhere.
gollark: Basically, I need a search engine for my personal files, except I have a *lot* of personal files and recoll is really slow.
gollark: And I'm not sure if that's reasonable.
gollark: Yes, but if I sell software, that might imply that it and the ideas within can be "owned" somehow.
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References
  1. "Research Accomplishments". Harbor-UCLA Medical Center. Retrieved 27 June 2014.
  2. Blakeslee, Sandra (3 February 1984). "Infertile woman has baby through embryo transfer". New York Times. Retrieved 27 June 2014.
  3. Friedrich, Otto (10 September 1984). "Medicine: A legal, moral, social nightmare". Time. Retrieved 27 June 2014.
  4. Wallis, Claudia (1984-09-10). "The New Origins of Life". Time. Retrieved 27 June 2014.
  5. Jares, Sue Ellen (1983-08-08). "A UCLA Doctor, First to Transplant Human Embryos, Offers Hope to Infertile Women". People. 20 (6). Retrieved 27 June 2014.
  6. "Assisted Reproductive Technology (ART)". Centers for Disease Control. Retrieved 27 June 2014.
  7. "Dead URL" (PDF). Sexuality, Reproduction and Menopause magazine. Archived from the original (PDF) on 2009-02-20.
  8. "Dead URL". Sexuality, Reproduction and Menopause magazine. Archived from the original on 2007-10-08.
  9. Mendell, Patricia; Benward, Jean. "Talking with Children About Ovum Donation". American Fertility Association - Infertility and Family Building. Archived from the original on 2013-05-11. Retrieved 27 June 2014.
  10. "John Buster, MD | Women & Infants' Fertility Center". Women & Infants' Fertility Center. Retrieved 2017-04-27.
  11. "Reproductive Endocrinology and Infertility Center". Tufts Medical Center. Retrieved 27 June 2014.
  12. England, Care New. "John Buster". www.womenandinfants.org. Retrieved 2016-07-27.
  13. "Buster, John". vivo.brown.edu. Retrieved 2016-07-27.
  14. "Brown University Fellowship in REI". Alpert Medical School of Brown University. Retrieved 27 June 2014.
  15. Buster, John (August 2012). "Sex and the 50-Something Woman". Contemporary OB/GYN. 57 (8): 32–39. Retrieved 27 June 2014.
  16. Reinsel Cotter, Pamela (2012). "When desire wanes". Providence Journal. Providence RI. Archived from the original on 2013-01-30. Retrieved 27 June 2014.
  17. https://academic.oup.com/jcem/article-abstract/48/1/139/2679266?redirectedFrom=fulltext
  18. Buster, John E.; Abraham, Guy E. (5 December 2006). "Radioimmunoassay of Plasma Dehydroepiandrosterone Sulfate". Analytical Letters. 5 (8): 543–551. doi:10.1080/00032717208062119.
  19. Abraham, G. E.; Buster, J. E.; Samojlik, E.; Garza, R.; Hillan, B. (February 1974). "Comparison Between Four Radioimmunoassays for Plasma Estriol". Analytical Letters. 7 (2): 119–123. doi:10.1080/00032717408058745.
  20. Buster, JE; Chang, RJ; Preston, DL; Elashoff, RM; Cousins, LM; Abraham, GE; Hobel, CJ; Marshall, JR (January 1979). "Interrelationships of circulating maternal steroid concentrations in third trimester pregnancies. I. C21 steroids: progesterone, 16 alpha-hydroxyprogesterone, 17 alpha-hydroxyprogesterone, 20 alpha-dihydroprogesterone, delta 5-pregnenolone, delta 5-pregnenolone sulfate, and 17-hydroxy delta 5-pregnenolone". The Journal of Clinical Endocrinology and Metabolism. 48 (1): 133–8. doi:10.1210/jcem-48-1-133. PMID 422695.
  21. https://www.contemporaryobgyn.net/modern-medicine-feature-articles/should-testosterone-therapy-be-used-treat-hsdd-reproductive-aged-women
  22. Buster, John E (January 2009). "Low-Dose Estradiol Spray: a Novel Treatment for Vasomotor Instability in Postmenopausal Women". Women's Health. 5 (1): 23–28. doi:10.2217/17455057.5.1.23. PMID 19102636.
  23. "FDA Approves Spray-On Estrogen to Treat Menopause". Fox News. 2008-06-02. Retrieved 27 June 2014.
  24. Buster, John E.; Koltun, William D.; Pascual, Maria Luz G.; Day, Wesley W.; Peterson, Craig (June 2008). "Low-Dose Estradiol Spray to Treat Vasomotor Symptoms". Obstetrics & Gynecology. 111 (6): 1343–1351. doi:10.1097/AOG.0b013e318175d162. PMID 18515518.
  25. Sauer, Mark V (editor) (1998). "1". Principles of Oocyte and Embryo Donation. New York: Springer-Verlag. pp. 1–10. ISBN 0387949607. Retrieved 27 June 2014.CS1 maint: extra text: authors list (link)
  26. "Embryo-Transfer Baby Born". The New York Times. New York: Arthur Ochs Sulzberger, Jr. 1984-03-25. Retrieved 27 June 2014.
  27. "Previvo Genetics - A New Choice in Pre-Implantation Genetic Diagnosis" Check |url= value (help). previvo.com. Retrieved 2016-07-27.
  28. "International Federation of Fertility Societies (IFFS)".
  29. "Human Reproduction (ESHRE)".
  30. "Medical researchers honored at LA Biomeds legends event". Daily Breeze. 2012-05-10. Retrieved 27 June 2014.
  31. "Physician to be honored as Legend" (Press release). Women & Infants Hospital of Rhode Island. Retrieved 27 June 2014.
  32. "Endowments - ACOG". www.acog.org. Retrieved 2016-07-27.
  33. "Subspecialty Sessions - ACOG". www.acog.org. Archived from the original on 2016-07-20. Retrieved 2016-07-27.
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