Sitagliptin/metformin

Sitagliptin/metformin, sold under the brand name Janumet among others, is a fixed-dose combination anti-diabetic medication used to treat type 2 diabetes.[2] It may be used in those whose blood sugar is not controlled with metformin and a sulfonylurea.[2][3] It is taken by mouth.[2]

Sitagliptin/metformin
Combination of
SitagliptinDipeptidyl peptidase-4 inhibitor
MetforminBiguanide
Clinical data
Trade namesJanumet, Januet, others
AHFS/Drugs.comProfessional Drug Facts
License data
Pregnancy
category
  • AU: C [1]
  • US: N (Not classified yet) [1]
    Routes of
    administration    		By mouth
    ATC code
    Legal status
    Legal status
    • AU: S4 (Prescription only)
    • US: ℞-only
    • In general: ℞ (Prescription only)
    Identifiers
    DrugBank
    UNII
    KEGG

    Common side effects include diarrhea, headache, and upper respiratory tract infections.[1] Serious side effects may include lactic acidosis, pancreatitis, low blood sugar, heart failure, joint pain, and allergic reactions.[1] It has not been properly studied in people who are pregnant or breastfeeding.[4] It contains sitagliptin (a dipeptidyl peptidase-4 inhibitor) and metformin (a biguanide).[1]

    The combination was approved for medical use in the United States in 2007.[1] In 2017, it was the 139th most commonly prescribed medication in the United States, with more than four million prescriptions.[5][6]

    Society and culture

    Brand names

    As of 2018, the combination was marketed under several brand names, including Efficib, Janmet, Januet, Janumet, Jznumet, Ristaben Met, Ristfor, Siglimet, Sitamet, Sitar-M, Sliptin-M, Treviamet, and Velmetia.[7]

    Price

    A month supply in the United Kingdom costs the NHS about 33.26 £ as of 2019.[2] In the United States the wholesale cost of this amount is about US$433.[8] In Denmark 100 tablets (each 1,000 mg) cost over the counter in a pharmacy DKK 62.60 = US$9.40 = £7.50, thus a month supply in Denmark costs DKK 37.50 = US$5.70 = £4.50. The pharmacy buys wholesale at DKK 33.83 = US$5.11 = £4.10.[9]

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    References
    1. "Janumet - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 19 April 2019.
    2. British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 682. ISBN 9780857113382.
    3. Hayes J, Anderson R, Stephens JW (2016). "Sitagliptin/metformin fixed-dose combination in type 2 diabetes mellitus: an evidence-based review of its place in therapy". Drug Design, Development and Therapy. 10: 2263–70. doi:10.2147/DDDT.S93076. PMC 4958358. PMID 27486305.
    4. "Metformin / sitagliptin Use During Pregnancy". Drugs.com. Retrieved 19 April 2019.
    5. "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
    6. "Metformin Hydrochloride; Sitagliptin Phosphate - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.
    7. "International brands for Sitagliptin/metformin". Drugs.com. Retrieved 3 September 2018.
    8. "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
    9. "Medicinpriser". Medicinpriser (in Danish). Retrieved 17 June 2019.
    • "Sitagliptin". Drug Information Portal. U.S. National Library of Medicine.
    • "Metformin". Drug Information Portal. U.S. National Library of Medicine.


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