Isoniazid/rifampicin

Isoniazid/rifampicin, also known as isoniazid/rifampin, is a medication used to treat tuberculosis.[1] It is a fixed dose combination of isoniazid and rifampicin (rifampin).[1] It is used together with other antituberculosis medication.[1] It is taken by mouth.[1]

Isoniazid/rifampicin
Combination of
IsoniazidAnti-tuberculosis medication
RifampicinAnti-tuberculosis medication
Clinical data
Trade namesIsonaRif, Rifamate, others
Pregnancy
category
  • US: C (Risk not ruled out)
    ATC code
    Identifiers
    KEGG

    It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[2]

    Adverse effects and safety

    Side effects are those of the underlying medications.[1] Common side effects include poor coordination, poor appetite, nausea, numbness, and feeling tired.[3] More severe side effects include liver problems.[3] Use is generally not recommended in children.[1] It is unclear if use is safe in pregnancy.[4]

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    References
    1. World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 142. hdl:10665/44053. ISBN 9789241547659.
    2. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
    3. "Isoniazid/rifampin Side Effects in Detail - Drugs.com". www.drugs.com. Archived from the original on 21 December 2016. Retrieved 18 December 2016.
    4. "Isoniazid / rifampin Use During Pregnancy | Drugs.com". www.drugs.com. Archived from the original on 21 December 2016. Retrieved 18 December 2016.
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