Canagliflozin/metformin

Canagliflozin/metformin, sold under the brand name Vokanamet among others, is a fixed-dose combination anti-diabetic medication used for the treatment of type 2 diabetes.[3][2][4] It is used in combination with diet and exercise.[3][2][4] It is taken by mouth.[3][2][4]

Canagliflozin/metformin
Combination of
CanagliflozinSGLT2 inhibitor
MetforminBiguanide
Clinical data
Trade namesVokanamet, Invokamet
AHFS/Drugs.comProfessional Drug Facts
License data
Pregnancy
category
  • US: N (Not classified yet) [1]
    Routes of
    administration    		By mouth
    ATC code
    Legal status
    Legal status
    • UK: POM (Prescription only) [2]
    • US: ℞-only
    • In general: ℞ (Prescription only)
    Identifiers
    KEGG

    It was approved for use in the European Union in April 2014,[3][2] and for use in the United States in August 2014.[5]

    Adverse effects

    To lessen the risk of developing ketoacidosis (a serious condition in which the body produces high levels of blood acids called ketones) after surgery, the FDA has approved changes to the prescribing information for SGLT2 inhibitor diabetes medicines to recommend they be stopped temporarily before scheduled surgery. Canagliflozin, dapagliflozin, and empagliflozin should each be stopped at least three days before, and ertugliflozin should be stopped at least four days before scheduled surgery.[6]

    Symptoms of ketoacidosis include nausea, vomiting, abdominal pain, tiredness, and trouble breathing.[6]

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    References
    1. "Canagliflozin / metformin Use During Pregnancy". Drugs.com. 10 September 2019. Retrieved 2 March 2020.
    2. "Vokanamet 50 mg/850 mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 13 February 2020. Retrieved 2 March 2020.
    3. "Vokanamet EPAR". European Medicines Agency (EMA). 18 February 2020. Retrieved 2 March 2020.
    4. "Invokamet- canagliflozin and metformin hydrochloride tablet, film coated Invokamet XR- canagliflozin and metformin hydrochloride tablet, film coated, extended release". DailyMed. 5 February 2020. Retrieved 2 March 2020.
    5. "Drug Approval Package: Invokamet (canagliflozin and metformin hydrochloride) Tablets NDA #204353". U.S. Food and Drug Administration (FDA). 4 September 2014. Retrieved 2 March 2020.
    6. "FDA revises labels of SGLT2 inhibitors for diabetes to include warning". U.S. Food and Drug Administration. 19 March 2020. Retrieved 6 June 2020. This article incorporates text from this source, which is in the public domain.

    Further reading


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