Insect cell culture

The use of insect cell lines as production hosts is an emerging technology for the production of bio pharmaceuticals. There are currently more than 100 insect cell lines available for recombinant protein production with lines derived from Bombyx mori, Mamestra brassicae, Spodoptera frugiperda, Trichoplusia ni, and Drosophila melanogaster being of particular interest. Insects cell lines are commonly used in place of prokaryotic ones because post-translational modifications of proteins are possible in insect cells whereas this mechanism is not present in prokaryotic systems.[1] The Sf9 cell line is one of the most commonly used lines in insect cell culture.[2]

References and notes
  1. Drugmand, Jean-Christophe; Schneider, Yves-Jacques; Agathos, Spiros N (2011). "Insect Cells as Factories for Biomanufacturing". Biotechnology Advances. 30 (5): 1140–57. doi:10.1016/j.biotechadv.2011.09.014. PMID 21983546.
  2. Drugmand, JC; Schneider, YJ; Agathos, SN (2012). "Insect cells as factories for biomanufacturing". Biotechnology Advances. 30 (5): 1140–57. doi:10.1016/j.biotechadv.2011.09.014. PMID 21983546.


gollark: Not really.
gollark: I've heard it said that you mostly can't beat the market and should just stick money in index funds.
gollark: Maybe just sell off and re-buy your shares every few months so they don't go stale.
gollark: But make sure to immediately sell them if the value drops at all.
gollark: You should only have shares in one company so you're more invested in their success.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.