Inflammatory fibroid polyp

Inflammatory fibroid polyp (IFP) is a benign abnormal growth of tissue projecting into the lumen of the gastrointestinal tract.

Inflammatory fibroid polyp
Micrograph of an inflammatory fibroid polyp. H&E stain.

Pathology

IFPs consist of spindle cells that are concentrically arranged around blood vessels and have inflammation, especially eosinophils.[1] They may have leiomyoma/schwannoma-like areas with nuclear palisading.

They typically stain with CD34[1] and vimentin,[2] and, generally, do not stain with CD117 and S100.

The endoscopic differential diagnosis includes other benign, pre-malignant and malignant gastrointestinal polyps.

  • High mag.

Morphological differential diagnosis
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See also


References
  1. Daum, O.; Hatlova, J.; Mandys, V.; Grossmann, P.; Mukensnabl, P.; Benes, Z.; Michal, M. (May 2010). "Comparison of morphological, immunohistochemical, and molecular genetic features of inflammatory fibroid polyps (Vanek's tumors)". Virchows Arch. 456 (5): 491–7. doi:10.1007/s00428-010-0914-8. PMID 20393746.
  2. Kolodziejczyk, P.; Yao, T.; Tsuneyoshi, M. (Nov 1993). "Inflammatory fibroid polyp of the stomach. A special reference to an immunohistochemical profile of 42 cases". Am J Surg Pathol. 17 (11): 1159–68. doi:10.1097/00000478-199311000-00009. PMID 8214261.
Classification
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