Indy (gene)

Indy, short for I'm not dead yet, is a gene found in the fruit fly Drosophila melanogaster, an important model organism. Mutant versions of this gene have doubled the average life span of fruit flies in at least one set of experiments, but this result has been subject to controversy. Both Indy proteins are sodium sulfate symporters.[1] Its name originates from a well-known comic line in Monty Python and the Holy Grail.[2]

I'm not dead yet
Identifiers
OrganismDrosophila melanogaster
SymbolIndy
UniProtQ9VVT2
I'm not dead yet 2
Identifiers
OrganismDrosophila melanogaster
SymbolIndy-2
UniProtQ9VDQ0

In a Yale University School of Medicine study by lead author and Howard Hughes Medical Institute investigator Gerald I. Shulman, the George R. Cowgill Professor of Physiological Chemistry, Medicine, and Cellular and Molecular Biology, reduced expression of this gene in Drosophila melanogaster flies and C. elegans worms (P32739) modeled the effects on obesity and diabetes of caloric reduction in primates such as humans. A similar effect was seen with SLC13A5 (mIndy) knockouts of mice.[3]

See also
  • Cellular biology

References
  1. Rogina B, Reenan RA, Nilsen SP, Helfand SL (15 December 2000). "Extended life-span conferred by cotransporter gene mutations in Drosophila". Science. 290 (5499): 2137–40. PMID 11118146.
  2. "Clever Drosophila gene names". Archived from the original on 2007-02-03. Retrieved 2007-02-15.
  3. "Diet, diabetes, and a gene called mINDY". Yale School of Medicine. Retrieved 25 May 2019.


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