Immunoglobulin lambda like polypeptide 5

Immunoglobulin lambda like polypeptide 5 is a protein that in humans is encoded by the IGLL5 gene. [5]

IGLL5
Identifiers
Aliases	IGLL5, IGL, IGLV, VL-MAR, immunoglobulin lambda like polypeptide 5
External IDs	MGI: 96529 HomoloGene: 131669 GeneCards: IGLL5
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.22 Start 22,887,780 bp[1] End 22,896,111 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A3|16 10.45 cM Start 16,860,671 bp[2] End 16,863,985 bp[2]
Gene ontology Molecular function • immunoglobulin receptor binding • antigen binding Cellular component • extracellular region • blood microparticle • extracellular exosome • external side of plasma membrane • immunoglobulin complex, circulating Biological process • B cell receptor signaling pathway • phagocytosis, recognition • positive regulation of B cell activation • phagocytosis, engulfment • innate immune system • defense response to bacterium • Classical complement pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	100423062	16136
Ensembl	ENSG00000254709	ENSMUSG00000075370
UniProt	B9A064	P20764
RefSeq (mRNA)	NM_001256296 NM_001178126	NM_001190325
RefSeq (protein)	NP_001171597 NP_001243225	NP_001177254
Location (UCSC)	Chr 22: 22.89 – 22.9 Mb	Chr 16: 16.86 – 16.86 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes one of the immunoglobulin lambda-like polypeptides. It is located within the immunoglobulin lambda locus but it does not require somatic rearrangement for expression. The first exon of this gene is unrelated to immunoglobulin variable genes; the second and third exons are the immunoglobulin lambda joining 1 and the immunoglobulin lambda constant 1 gene segments. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].

References

1. GRCh38: Ensembl release 89: ENSG00000254709 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000075370 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Immunoglobulin lambda like polypeptide 5". Retrieved 2017-10-23.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.