IRS4

Insulin receptor substrate 4 is a protein that in humans is encoded by the IRS4 gene.[2][3][4]

IRS4
Identifiers
AliasesIRS4, IRS-4, PY160, insulin receptor substrate 4, CHNG9
External IDsOMIM: 300904 HomoloGene: 136777 GeneCards: IRS4
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8471

n/a

Ensembl

n/a

n/a

UniProt

O14654

n/a

RefSeq (mRNA)

NM_003604
NM_001379150

n/a

RefSeq (protein)

NP_003595
NP_001366079

n/a

Location (UCSC)n/an/a
PubMed search[1]n/a
Wikidata
View/Edit Human

IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.[4]

Interactions

IRS4 has been shown to interact with CRK[5][6] and NISCH.[7]

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gollark: But generally you would just be inconveniently prevented from seeing me.
gollark: *Potentially*, you might through sheer coincidence end up "seeing" me due to there randomly being photons of the right wavelength/direction/whatever.
gollark: Actually, that's not known.
gollark: Computers randomly malfunction to make it appear that I exist.

References
  1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. Lavan BE, Fantin VR, Chang ET, Lane WS, Keller SR, Lienhard GE (Sep 1997). "A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family". J Biol Chem. 272 (34): 21403–7. doi:10.1074/jbc.272.34.21403. PMID 9261155.
  3. Fantin VR, Sparling JD, Slot JW, Keller SR, Lienhard GE, Lavan BE (May 1998). "Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells". J Biol Chem. 273 (17): 10726–32. doi:10.1074/jbc.273.17.10726. PMID 9553137.
  4. "Entrez Gene: IRS4 insulin receptor substrate 4".
  5. Karas, M; Koval A P; Zick Y; LeRoith D (May 2001). "The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II". Endocrinology. United States. 142 (5): 1835–40. doi:10.1210/en.142.5.1835. ISSN 0013-7227. PMID 11316748.
  6. Koval, A P; Karas M; Zick Y; LeRoith D (Jun 1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction". J. Biol. Chem. UNITED STATES. 273 (24): 14780–7. doi:10.1074/jbc.273.24.14780. ISSN 0021-9258. PMID 9614078.
  7. Sano, Hiroyuki; Liu Simon C H; Lane William S; Piletz John E; Lienhard Gustav E (May 2002). "Insulin receptor substrate 4 associates with the protein IRAS". J. Biol. Chem. United States. 277 (22): 19439–47. doi:10.1074/jbc.M111838200. ISSN 0021-9258. PMID 11912194.

Further reading


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