IQGAP2

Ras GTPase-activating-like protein IQGAP2 is an enzyme that in humans is encoded by the IQGAP2 gene.[5][6]

IQGAP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IEZ, 4EZA
Identifiers
Aliases	IQGAP2, IQ motif containing GTPase activating protein 2
External IDs	OMIM: 605401 MGI: 2449975 HomoloGene: 101543 GeneCards: IQGAP2
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q13.3 Start 76,403,285 bp[1] End 76,708,132 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 D1|13 50.26 cM Start 95,627,174 bp[2] End 95,892,483 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • Rac GTPase binding • Arp2/3 complex binding • GTPase inhibitor activity • actin filament binding • Rho GTPase binding • actin binding • phosphatidylinositol-3,4,5-trisphosphate binding • calmodulin binding Cellular component • cytoplasm • filamentous actin • cytosol • filopodium • microvilli • cell surface • actin cytoskeleton • microtubule • extracellular exosome • lamellipodium • cell membrane • secretory granule membrane Biological process • thrombin-activated receptor signaling pathway • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • Arp2/3 complex-mediated actin nucleation • signal transduction • GO:0034259 negative regulation of GTPase activity • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10788	544963
Ensembl	ENSG00000145703	ENSMUSG00000021676
UniProt	Q13576	Q3UQ44
RefSeq (mRNA)	NM_001285460 NM_001285461 NM_001285462 NM_006633	NM_027711
RefSeq (protein)	NP_001272389 NP_001272390 NP_001272391 NP_006624	NP_081987
Location (UCSC)	Chr 5: 76.4 – 76.71 Mb	Chr 13: 95.63 – 95.89 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility.[6]

Interactions

IQGAP2 has been shown to interact with CDC42[5] and RAC1.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000145703 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021676 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Brill S, Li S, Lyman CW, Church DM, Wasmuth JJ, Weissbach L, Bernards A, Snijders AJ (Sep 1996). "The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases". Mol. Cell. Biol. 16 (9): 4869–78. doi:10.1128/mcb.16.9.4869. PMC 231489. PMID 8756646.
6. "Entrez Gene: IQGAP2 IQ motif containing GTPase activating protein 2".

Further reading

• McCallum SJ, Wu WJ, Cerione RA (1996). "Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2". J. Biol. Chem. 271 (36): 21732–7. doi:10.1074/jbc.271.36.21732. PMID 8702968.
• Yin H, Morioka H, Towle CA, Vidal M, Watanabe T, Weissbach L (2001). "Evidence that HAX-1 is an interleukin-1 alpha N-terminal binding protein". Cytokine. 15 (3): 122–37. doi:10.1006/cyto.2001.0891. PMID 11554782.
• Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K, Der CJ (2002). "RhoG signals in parallel with Rac1 and Cdc42". J. Biol. Chem. 277 (49): 47810–7. doi:10.1074/jbc.M203816200. PMID 12376551.
• Schmidt VA, Scudder L, Devoe CE, Bernards A, Cupit LD, Bahou WF (2003). "IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization". Blood. 101 (8): 3021–8. doi:10.1182/blood-2002-09-2807. PMID 12515716.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Chew CS, Okamoto CT, Chen X, Qin HY (2005). "IQGAPs are differentially expressed and regulated in polarized gastric epithelial cells". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (2): G376-87. doi:10.1152/ajpgi.00290.2004. PMID 15458922.
• Wang H, Huo R, Xu M, Lu L, Xu Z, Li J, Zhou Z, Sha J (2005). "Cloning and characterization of a novel transcript variant of IQGAP2 in human testis". DNA Seq. 15 (5–6): 319–25. doi:10.1080/10425170400009012. PMID 15621655.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.