IPO13

Importin-13 is a protein that in humans is encoded by the IPO13 gene.[5][6][7]

IPO13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2X19, 2XWU, 3ZJY
Identifiers
Aliases	IPO13, IMP13, KAP13, LGL2, RANBP13, importin 13
External IDs	OMIM: 610411 MGI: 2385205 HomoloGene: 40968 GeneCards: IPO13
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.1 Start 43,946,950 bp[1] End 43,968,022 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.1 Start 117,894,486 bp[2] End 117,914,999 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • Ran GTPase binding • nuclear localization sequence binding Cellular component • cell nucleus • nuclear membrane • cytoplasm Biological process • protein import into nucleus • protein transport • intracellular protein transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9670	230673
Ensembl	ENSG00000117408	ENSMUSG00000033365
UniProt	O94829	Q8K0C1
RefSeq (mRNA)	NM_014652	NM_146152
RefSeq (protein)	NP_055467	NP_666264
Location (UCSC)	Chr 1: 43.95 – 43.97 Mb	Chr 4: 117.89 – 117.91 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

IPO13 has been shown to interact with RBM8A,[6] PAX6,[8][9] ALX1,[9] EIF1AX[6] and UBE2I.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000117408 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033365 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
6. Mingot JM, Kostka S, Kraft R, Hartmann E, Görlich D (Jul 2001). "Importin 13: a novel mediator of nuclear import and export". The EMBO Journal. 20 (14): 3685–94. doi:10.1093/emboj/20.14.3685. PMC 125545. PMID 11447110.
7. "Entrez Gene: IPO13 importin 13".
8. Ploski JE, Shamsher MK, Radu A (Jun 2004). "Paired-type homeodomain transcription factors are imported into the nucleus by karyopherin 13". Molecular and Cellular Biology. 24 (11): 4824–34. doi:10.1128/MCB.24.11.4824-4834.2004. PMC 416398. PMID 15143176.
9. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

• Ploski JE, Shamsher MK, Radu A (Jun 2004). "Paired-type homeodomain transcription factors are imported into the nucleus by karyopherin 13". Molecular and Cellular Biology. 24 (11): 4824–34. doi:10.1128/MCB.24.11.4824-4834.2004. PMC 416398. PMID 15143176.
• Zhang C, Sweezey NB, Gagnon S, Muskat B, Koehler D, Post M, Kaplan F (Apr 2000). "A novel karyopherin-beta homolog is developmentally and hormonally regulated in fetal lung". American Journal of Respiratory Cell and Molecular Biology. 22 (4): 451–9. doi:10.1165/ajrcmb.22.4.3929. PMID 10745026.