InaD-like protein

InaD-like protein is a protein that in humans is encoded by the PATJ gene.[5][6][7]

PATJ
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPATJ, Cipp, InaD-like, hINADL, INADL, crumbs cell polarity complex component, PATJ crumbs cell polarity complex component
External IDsOMIM: 603199 MGI: 1277960 HomoloGene: 72199 GeneCards: PATJ
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p31.3Start61,742,406 bp[1]
End62,178,675 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10207

12695

Ensembl

ENSG00000132849

ENSMUSG00000061859

UniProt

Q8NI35

Q63ZW7

RefSeq (mRNA)

NM_005799
NM_176877
NM_176878
NM_001350145

NM_001005784
NM_001005787
NM_007704
NM_172696
NM_001355177

RefSeq (protein)

NP_795352
NP_001337074

NP_001005784
NP_001005787
NP_031730
NP_766284
NP_001342106

Location (UCSC)Chr 1: 61.74 – 62.18 MbChr 4: 98.4 – 98.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors.[7]

Interactions

INADL has been shown to interact with MPP5.[8]

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gollark: It really annoys me that countries' "security" agencies go around hoarding exploits in stuff.
gollark: Well, yes, because they wanted an anonymous network of some sort.
gollark: One would imagine they *run* a bunch of tor nodes.

References

  1. GRCh38: Ensembl release 89: ENSG00000132849 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000061859 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Philipp S, Flockerzi V (Sep 1997). "Molecular characterization of a novel human PDZ domain protein with homology to INAD from Drosophila melanogaster". FEBS Lett. 413 (2): 243–8. doi:10.1016/S0014-5793(97)00877-6. PMID 9280290.
  6. Soejima H, Kawamoto S, Akai J, Miyoshi O, Arai Y, Morohka T, Matsuo S, Niikawa N, Kimura A, Okubo K, Mukai T (May 2001). "Isolation of novel heart-specific genes using the BodyMap database". Genomics. 74 (1): 115–20. doi:10.1006/geno.2001.6527. PMID 11374908.
  7. "Entrez Gene: INADL InaD-like (Drosophila)".
  8. Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B (Apr 2002). "The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost". J. Cell Biol. 157 (1): 161–72. doi:10.1083/jcb.200109010. PMC 2173254. PMID 11927608.

Further reading


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