ILKAP

Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene.[5]

ILKAP
Identifiers
Aliases	ILKAP, ILKAP2, ILKAP3, PP2C-DELTA, PPM1O, ILK associated serine/threonine phosphatase
External IDs	MGI: 1914694 HomoloGene: 31525 GeneCards: ILKAP
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 238,170,402 bp[1] End 238,203,708 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 91,373,861 bp[2] End 91,398,815 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein serine/threonine phosphatase activity • GO:0001948 protein binding • catalytic activity • phosphoprotein phosphatase activity • hydrolase activity • metal ion binding • cation binding • magnesium-dependent protein serine/threonine phosphatase activity Cellular component • cytoplasm • cell nucleus • nucleoplasm • cytosol Biological process • protein dephosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80895	67444
Ensembl	ENSG00000132323	ENSMUSG00000026309
UniProt	Q9H0C8	Q8R0F6
RefSeq (mRNA)	NM_030768 NM_176799	NM_023343 NM_001355152
RefSeq (protein)	NP_110395	NP_075832 NP_001342081
Location (UCSC)	Chr 2: 238.17 – 238.2 Mb	Chr 1: 91.37 – 91.4 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.[5]

Interactions

ILKAP has been shown to interact with Integrin-linked kinase.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000132323 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026309 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2C".
6. Leung-Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan GE (May 2001). "Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1". The EMBO Journal. 20 (9): 2160–70. doi:10.1093/emboj/20.9.2160. PMC 125446. PMID 11331582.

Further reading

• Tong Y, Quirion R, Shen SH (December 1998). "Cloning and characterization of a novel mammalian PP2C isozyme". The Journal of Biological Chemistry. 273 (52): 35282–90. doi:10.1074/jbc.273.52.35282. PMID 9857069.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Leung-Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan GE (May 2001). "Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1". The EMBO Journal. 20 (9): 2160–70. doi:10.1093/emboj/20.9.2160. PMC 125446. PMID 11331582.
• Kumar AS, Naruszewicz I, Wang P, Leung-Hagesteijn C, Hannigan GE (April 2004). "ILKAP regulates ILK signaling and inhibits anchorage-independent growth". Oncogene. 23 (19): 3454–61. doi:10.1038/sj.onc.1207473. PMID 14990992.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.