Immunoglobulin superfamily member 3

Immunoglobulin superfamily member 3 is a protein that in humans is encoded by the IGSF3 gene. [5]

IGSF3
Identifiers
Aliases	IGSF3, EWI-3, V8, LCDD, immunoglobulin superfamily member 3
External IDs	OMIM: 603491 MGI: 1926158 HomoloGene: 1182 GeneCards: IGSF3
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.1 Start 116,574,399 bp[1] End 116,667,755 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.2|3 44.3 cM Start 101,377,083 bp[2] End 101,463,059 bp[2]
Gene ontology Molecular function • molecular function Cellular component • membrane • cell surface • cell membrane • integral component of membrane Biological process • lacrimal gland development • cell surface receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3321	78908
Ensembl	ENSG00000143061	ENSMUSG00000042035
UniProt	O75054	Q6ZQA6
RefSeq (mRNA)	NM_001007237 NM_001542	NM_207205
RefSeq (protein)	NP_001007238 NP_001533	NP_997088
Location (UCSC)	Chr 1: 116.57 – 116.67 Mb	Chr 3: 101.38 – 101.46 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is an immunoglobulin-like membrane protein containing several V-type Ig-like domains. A mutation in this gene has been associated with bilateral nasolacrimal duct obstruction (LCDD). [provided by RefSeq, Jun 2016].

References

1. GRCh38: Ensembl release 89: ENSG00000143061 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042035 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Immunoglobulin superfamily member 3". Retrieved 2018-10-06.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.