IFT57

Intraflagellar transport protein 57 homolog is a protein that in humans is encoded by the IFT57 gene.[5]

IFT57
Identifiers
Aliases	IFT57, ESRRBL1, HIPPI, MHS4R2, intraflagellar transport 57, OFD18
External IDs	OMIM: 606621 MGI: 1921166 HomoloGene: 32383 GeneCards: IFT57
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.12-q13.13 Start 108,160,812 bp[1] End 108,222,435 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B5 Start 49,699,233 bp[2] End 49,765,126 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding Cellular component • intraciliary transport particle B • cytoplasm • ciliary basal body • centrosome • Golgi apparatus • cell projection • photoreceptor connecting cilium • dendrite terminus • ciliary tip • GO:0035085 axoneme • cytoskeleton • cilium Biological process • regulation of apoptotic process • regulation of transcription, DNA-templated • intraciliary transport • transcription, DNA-templated • heart looping • neural tube closure • negative regulation of epithelial cell proliferation • smoothened signaling pathway • left/right pattern formation • activation of cysteine-type endopeptidase activity involved in apoptotic process • apoptotic process • intraciliary transport involved in cilium assembly • motile cilium assembly • non-motile cilium assembly • cilium morphogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55081	73916
Ensembl	ENSG00000114446	ENSMUSG00000032965
UniProt	Q9NWB7	Q8BXG3
RefSeq (mRNA)	NM_018010	NM_028680
RefSeq (protein)	NP_060480	NP_082956
Location (UCSC)	Chr 3: 108.16 – 108.22 Mb	Chr 16: 49.7 – 49.77 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

IFT57 has been shown to interact with Caspase 8.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000114446 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032965 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: IFT57 intraflagellar transport 57 homolog (Chlamydomonas)".
6. Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW (Feb 2002). "Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi". Nat. Cell Biol. 4 (2): 95–105. doi:10.1038/ncb735. PMID 11788820.

Further reading

• Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW (2002). "Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi". Nat. Cell Biol. 4 (2): 95–105. doi:10.1038/ncb735. PMID 11788820.
• Mattson MP (2002). "Accomplices to neuronal death" (PDF). Nature. 415 (6870): 377–9. doi:10.1038/415377a. PMID 11807533.
• Cheng CM, Huang SP, Chang YF, Chung WY, Yuo CY (2003). "The viral death protein Apoptin interacts with Hippi, the protein interactor of Huntingtin-interacting protein 1". Biochem. Biophys. Res. Commun. 305 (2): 359–64. doi:10.1016/S0006-291X(03)00764-2. PMID 12745083.
• Baker SA, Freeman K, Luby-Phelps K, Pazour GJ, Besharse JC (2003). "IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia". J. Biol. Chem. 278 (36): 34211–8. doi:10.1074/jbc.M300156200. PMID 12821668.
• Fan Y, Esmail MA, Ansley SJ, Blacque OE, Boroevich K, Ross AJ, Moore SJ, Badano JL, May-Simera H, Compton DS, Green JS, Lewis RA, van Haelst MM, Parfrey PS, Baillie DL, Beales PL, Katsanis N, Davidson WS, Leroux MR (2004). "Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome". Nat. Genet. 36 (9): 989–93. doi:10.1038/ng1414. PMID 15314642.
• Majumder P, Chattopadhyay B, Mazumder A, Das P, Bhattacharyya NP (2006). "Induction of apoptosis in cells expressing exogenous Hippi, a molecular partner of huntingtin-interacting protein Hip1". Neurobiol. Dis. 22 (2): 242–56. doi:10.1016/j.nbd.2005.11.003. PMID 16364650.
• Banerjee M, Majumder P, Bhattacharyya NP, Dattagupta JK, Sen U (2006). "Cloning, expression, purification, crystallization and preliminary crystallographic analysis of pseudo death-effector domain of HIPPI, a molecular partner of Huntingtin-interacting protein HIP-1". Acta Crystallographica Section F. 62 (Pt 12): 1247–50. doi:10.1107/S1744309106046628. PMC 2225382. PMID 17142908.
• Majumder P, Chattopadhyay B, Sukanya S, Ray T, Banerjee M, Mukhopadhyay D, Bhattacharyya NP (2007). "Interaction of HIPPI with putative promoter sequence of caspase-1 in vitro and in vivo". Biochem. Biophys. Res. Commun. 353 (1): 80–5. doi:10.1016/j.bbrc.2006.11.138. PMID 17173859.