IFIT3

Interferon-induced protein with tetratricopeptide repeats 3 is a protein that in humans is encoded by the IFIT3 gene.[5][6][7]

IFIT3
Identifiers
Aliases	IFIT3, CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, P60, RIG-G, cig41, interferon induced protein with tetratricopeptide repeats 3
External IDs	OMIM: 604650 MGI: 1101055 HomoloGene: 1189 GeneCards: IFIT3
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.31 Start 89,327,997 bp[1] End 89,340,971 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C1 Start 34,583,531 bp[2] End 34,588,731 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • identical protein binding • GO:0001948 protein binding • molecular function • RNA binding Cellular component • cytoplasm • mitochondrion • cytosol Biological process • immune system process • response to virus • innate immune system • negative regulation of apoptotic process • defense response to virus • type I interferon signaling pathway • negative regulation of cell proliferation • cellular response to interferon-alpha • response to bacterium • cellular response to interferon-beta Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3437	15959
Ensembl	ENSG00000119917	ENSMUSG00000074896
UniProt	O14879	Q64345
RefSeq (mRNA)	NM_001549 NM_001031683 NM_001289758 NM_001289759	NM_010501
RefSeq (protein)	NP_001026853 NP_001276687 NP_001276688 NP_001540	NP_034631
Location (UCSC)	Chr 10: 89.33 – 89.34 Mb	Chr 19: 34.58 – 34.59 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000119917 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074896 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. de Veer MJ, Sim H, Whisstock JC, Devenish RJ, Ralph SJ (Jan 1999). "IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes". Genomics. 54 (2): 267–77. doi:10.1006/geno.1998.5555. PMID 9828129.
6. Zhu H, Cong JP, Shenk T (Jan 1998). "Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs". Proc Natl Acad Sci U S A. 94 (25): 13985–90. doi:10.1073/pnas.94.25.13985. PMC 28419. PMID 9391139.
7. "Entrez Gene: IFIT3 interferon-induced protein with tetratricopeptide repeats 3".

Further reading

• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
• Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yu M, Tong JH, Mao M, et al. (1997). "Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7406–11. doi:10.1073/pnas.94.14.7406. PMC 23834. PMID 9207104.