ICMT

Protein-S-isoprenylcysteine O-methyltransferase is an enzyme that in humans is encoded by the ICMT gene.[5][6][7]

For the physics institute, see Institute for Condensed Matter Theory.

ICMT
Identifiers
Aliases	ICMT, HSTE14, MST098, MSTP098, PCCMT, PCMT, PPMT, isoprenylcysteine carboxyl methyltransferase
External IDs	OMIM: 605851 MGI: 1888594 HomoloGene: 5735 GeneCards: ICMT
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.31 Start 6,221,193 bp[1] End 6,235,972 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 152,297,227 bp[2] End 152,307,121 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • methyltransferase activity • transferase activity • protein C-terminal carboxyl O-methyltransferase activity • protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity Cellular component • integral component of membrane • endoplasmic reticulum membrane • endoplasmic reticulum • membrane Biological process • post-translational modification • methylation • cellular protein modification process • protein targeting to membrane • C-terminal protein methylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23463	57295
Ensembl	ENSG00000116237	ENSMUSG00000039662
UniProt	O60725	Q9EQK7
RefSeq (mRNA)	NM_012405 NM_170705	NM_133788
RefSeq (protein)	NP_036537	NP_598549
Location (UCSC)	Chr 1: 6.22 – 6.24 Mb	Chr 4: 152.3 – 152.31 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000116237 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039662 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dai Q, Choy E, Chiu V, Romano J, Slivka SR, Steitz SA, Michaelis S, Philips MR (Jul 1998). "Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum". J Biol Chem. 273 (24): 15030–4. doi:10.1074/jbc.273.24.15030. PMID 9614111.
6. Desrosiers RR, Nguyen QT, Beliveau R (Sep 1999). "The carboxyl methyltransferase modifying G proteins is a metalloenzyme". Biochem Biophys Res Commun. 261 (3): 790–7. doi:10.1006/bbrc.1999.0936. PMID 10441503.
7. "Entrez Gene: ICMT isoprenylcysteine carboxyl methyltransferase".

Further reading

• Choy E, Chiu VK, Silletti J, et al. (1999). "Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi". Cell. 98 (1): 69–80. doi:10.1016/S0092-8674(00)80607-8. PMID 10412982.
• Lin X, Antalffy B, Kang D, et al. (2000). "Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1". Nat. Neurosci. 3 (2): 157–63. doi:10.1038/72101. PMID 10649571.
• Van Dessel GA, De Busser HM, Lagrou AR (2002). "Prenylcysteine carboxymethyltransferase type III activity is decreased in retinoic acid-treated SH-SY5Y neuroblastoma cells". Int. J. Biochem. Cell Biol. 34 (5): 477–86. doi:10.1016/S1357-2725(01)00151-0. PMID 11906819.
• Ahmad M, Zhang Y, Zhang Y, et al. (2002). "Role of isoprenylcysteine carboxyl methyltransferase in tumor necrosis factor-alpha stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells". Arterioscler. Thromb. Vasc. Biol. 22 (5): 759–64. doi:10.1161/01.ATV.0000015884.61894.DC. PMID 12006387.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kramer K, Harrington EO, Lu Q, et al. (2004). "Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis". Mol. Biol. Cell. 14 (3): 848–57. doi:10.1091/mbc.E02-07-0390. PMC 151564. PMID 12631708.
• Winter-Vann AM, Kamen BA, Bergo MO, et al. (2003). "Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate". Proc. Natl. Acad. Sci. U.S.A. 100 (11): 6529–34. doi:10.1073/pnas.1135239100. PMC 164480. PMID 12750467.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bergo MO, Gavino BJ, Hong C, et al. (2004). "Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf". J. Clin. Invest. 113 (4): 539–50. doi:10.1172/JCI18829. PMC 338259. PMID 14966563.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lu Q, Harrington EO, Newton J, et al. (2007). "Inhibition of ICMT induces endothelial cell apoptosis through GRP94". Am. J. Respir. Cell Mol. Biol. 37 (1): 20–30. doi:10.1165/rcmb.2006-0301SM. PMC 1899353. PMID 17347446.