Hsp90 cis-regulatory element
The Hsp90 cis regulatory element is an RNA element (RNA thermometer) found in the 5' UTR of the Drosophila hsp90 mRNA. It is required for increased translational efficiency during the heat shock response.
| Hsp90 cis-regulatory element | |
|---|---|
 Predicted secondary structure and sequence conservation of Hsp90_CRE | |
| Identifiers | |
| Symbol | Hsp90_CRE |
| Rfam | RF00433 |
| Other data | |
| RNA type | Cis-reg; thermoregulator |
| Domain(s) | Eukaryota |
| SO | 0000233 |
| PDB structures | PDBe |
The hsp90 gene product is involved in the Drosophila heat shock response. Translation of the hsp90 mRNA is very inefficient under normal growth temperatures, when heat shock occurs translation becomes more efficient. This is mediated though this regulatory element.[1]
See also
References
- Ahmed R, Duncan RF (November 2004). "Translational regulation of Hsp90 mRNA. AUG-proximal 5'-untranslated region elements essential for preferential heat shock translation". The Journal of Biological Chemistry. 279 (48): 49919–49930. doi:10.1074/jbc.M404681200. PMID 15347681.
External links
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