Hermann Pauly

Hermann Pauly (18 July 1870 – 31 October 1950) was a German chemist and inventor. He is known for the Pauly reaction, a chemical test used for detecting the presence of tyrosine or histidine in proteins.

Hermann Pauly
Pauly c. 1932
Born	(1870-07-18)18 July 1870 Deutz, North German Confederation
Died	31 October 1950(1950-10-31) (aged 80) Würzburg, West Germany
Nationality	German
Occupation	Chemist, inventor
Known for	Pauly reaction

Early years

Hermann Pauly was born in Deutz (now part of Cologne) on 18 July 1870. His father was Friedrich Hermann Pauly, a mine director, and his mother was Henriette Wintgens (or Wittgens).[1] He graduated from the Adolfinum Moers Hermann secondary school, then studied natural sciences at the University of Giessen in Hesse, Leipzig University and the Rheinische Friedrich-Wilhelms University of Bonn.[2] He became a member of the Corps Teutonia Bonn in 1890.[3] He studied chemistry under Richard Anschütz in Bonn, and gained a PhD in 1894.[2][4]

Career

Pauly worked for a short period at Schering AG in Berlin, then became a research assistant to Hermann Emil Fischer at the Friedrich-Wilhelms-Universität. He then became a teaching assistant to Rudolf Nietzki at the University of Basel.[2] He returned to Bonn, where he qualified as a professor in 1901.[5] In 1904, he joined Albrecht Kossel at Heidelberg University.[2] Pauly studied for his habilitation at the University of Würzburg, and was appointed an assistant professor in 1909. In 1912 he joined a private laboratory. In 1918 he was appointed a full Professor at Würzburg.[2] Pauly became a member of the Corpsschleifenträger der Lusatia Leipzig in 1922.[6] Hermann Pauly was awarded an honorary doctorate in medicine in 1932. He died in Würzburg on 31 October 1950.[2]

Work

Pauly published 71 papers on organic chemistry and physiological chemistry and filed at least 14 patents related to pharmaceutical products, fragrances and antiseptic preparations.[2][lower-alpha 1] He correctly confirmed the finding of Thomas Aldrich that the formula for adrenaline was C₉H₁₃NO₃ despite the fact that he was not working with pure samples, which only emerged much later.[8] Pauly spent many years studying the diazo-reactions of proteins.[9] In 1904 he published a paper that described what became known as the Pauly reaction, a method of detecting the presence of the amino acids tyrosine or histidine in proteins.[2][10] In 1915 Pauly used diazo-benzene arsinic acid rather than diazo-benzene sulphonic acid to prepare an insoluble diazo-compound. He found that a tyrosine ring took on two molecules of the diazo-compound to form a bis-diazo-tyrosine. A histidine ring did the same.[9] These discoveries proved invaluable to the work of Karl Landsteiner on immunity and allergy.[11]

Publications

• H. Pauly (1899). Patente u. a. Verfahren z. Darst. v. α-Tetramethylpyrrolidin-β-karbonsäureamiden u. deren n-Alkylderivaten. DRP 109346.
• H. Pauly (1902). "Studien in der Reihe der Hydropyrrole". Liebigs Ann. Chem. 322: 77–130.
• H. Pauly (1903). "Zur Kenntnis d. Adrenalins". Berr. d. dt. chem. 36: 2944–49.
• H. Pauly; A. Binz (1904). "Seide u. Wolle als Farbstoffbildner". Zs. f. Farben- u. Textilind. 3: 373 ff.
• H. Pauly (1904). "Über die Konstitution des Histidins. I. Mitteilung". Z. Physiol. Chem. Hoppe-Seyler. 42: 508–518. doi:10.1515/bchm2.1904.42.5-6.508.CS1 maint: ref=harv (link)
• H. Pauly; K. Gundermann (1908). "Über jodbindende Systeme". Eiweiß-Spaltkörpern. 41: 3999–4012.
• H. Pauly; K. Gundermann (1908). Verfahren z. Darst. v. kernjodierten Imidazolen. DRP 223303.
• H. Pauly (1910). Über jodierte Abkömmlinge d. Imidazols u. d. Histidins. 43. pp. 2243–61.
• H. Pauly (1910). Über einige Verbindungen d. Histidins. 64. pp. 75–81.
• H. Pauly; E. Arauner (1928). "Über d. Gegensatz zw. Jod u. Brom bei d. Imidazolsubstitution". Journal f. prakt. Chemie. 118: 33–47.
• H. Pauly; W. Neumann (1937). "Über pharmakolog. Wirkungen jodierter Imidazolverbindungen, insbes. auf d. Stoffwechsel". Archiv f. experimentelle Pathol. u. Pharmakol. 187: 571 ff.
• H. Pauly (1948). "Scheidung v. Ligninkomponenten II., Addukte mit Maleinsäureanhydrid". Chem. Ber. 81: 392–99.

Notes

1. The cuprammonium process for making rayon using Schweizer's reagent had been patented in 1890 by the French chemist Louis Henri Despeissis. Despeissis died in 1892 and his patent was not renewed.[7] The partners Max Fremery and Johann Urban decided to move into artificial textile manufacture. They developed a version of the Despeissis process with the addition of a practical method for spinning the fiber. They filed the patent for this process in 1897 under Pauly's name so as not to alert their competitors. Pauly, then teaching the Mönchengladbach technical school, was not further involved in development of the product.[7]

1. Marquart 2001, p. 137.
2. Marquart 2001, pp. 138.
3. Gerlach 1930, p. 17, 320.
4. Pauly 1894.
5. Pauly 1901.
6. Gerlach 1930, p. 93, 858.
7. Woodings 2001, p. 5.
8. Hoffman 2013, p. 1875.
9. Mazumdar 2002, p. 249.
10. H. Pauly 1904, pp. 508–518.
11. Mazumdar 2002, p. 250.

Sources

• Gerlach, Otto (1930). Kösener Corpslisten.CS1 maint: ref=harv (link)
• Hoffman, Brian B. (2013-04-15). Adrenaline. Harvard University Press. ISBN 978-0-674-07473-6. Retrieved 2015-10-12.CS1 maint: ref=harv (link)
• Marquart, Hans-Wilhelm (2001). "Pauly, Hermann". Neue deutsche Biographie (in German). 20. Berlin: Pagenstecher – Püterich. ISBN 3-428-00201-6. Retrieved 2015-09-23.CS1 maint: ref=harv (link)
• Mazumdar, Pauline M. H. (2002-07-18). Species and Specificity: An Interpretation of the History of Immunology. Cambridge University Press. ISBN 978-0-521-52523-7. Retrieved 2015-10-12.CS1 maint: ref=harv (link)
• Pauly, Hermann (1894). Dissertation: Beiträge zur Kenntnis der Dioxobernsteinsäureester.CS1 maint: ref=harv (link)
• Pauly, Hermann (1901). Habilitationsschrift: Studien in der Reihe der Hydropyrrole.CS1 maint: ref=harv (link)
• Woodings, C (2001-04-30). Regenerated Cellulose Fibres. Elsevier. ISBN 978-1-85573-758-7. Retrieved 2015-09-16.CS1 maint: ref=harv (link)